Aims & Objective: Armoracia rusticana has high medicinal values and is an excellent source of phytochemicals. This study was aimed to evaluate the antidiabetic potential of bioactive compounds from Armoracia rusticana.

Methods: The antidiabetic analysis revealed that Armoracia rusticana was highly active against α- glucosidase with IC50 values of 5.6 μg/ml. Furthermore, molecular docking was used to identify the active constituents against α-glucosidase, while using acarbose as a controlled drug.

Results: Upon phytochemical screening, it was found that six out of ten phytochemicals were successfully docked in the respective binding sites. The lead phytochemical was Quercetin 3-Obeta- D-xylopyranoside, which displayed a more binding score as compared to acarbose. They were subjected to analyze for drug-like properties, which further strengthen its validation.

Conclusion: It was, therefore, concluded that Armoracia rusticana might potentially be used in the amelioration of type 2 diabetes. Potential molecules identified from this study could be considered as a lead drug to cure diabetes mellitus.

目的与目的：Armoracia rusticana 具有很高的药用价值，是植物化学物质的极好来源。本研究旨在评估来自 Armaracia rusticana 的生物活性化合物的抗糖尿病潜力。

方法：抗糖尿病分析表明，Armoracia rusticana 对 α-葡萄糖苷酶具有高度活性，IC50 值为 5.6 μg/ml。此外，分子对接用于鉴定针对α-葡萄糖苷酶的活性成分，同时使用阿卡波糖作为受控药物。

结果：通过植物化学筛选，发现十分之六的植物化学物质成功地对接在各自的结合位点。领先的植物化学物质是槲皮素 3-Obeta-D-吡喃木糖苷，与阿卡波糖相比，其显示出更高的结合分数。他们对类似药物的特性进行了分析，这进一步加强了其验证。

结论：因此，得出结论，Armoracia rusticana 可能用于改善 2 型糖尿病。从这项研究中确定的潜在分子可以被视为治疗糖尿病的先导药物。