NUT midline carcinoma (NMC) is an aggressive neoplasm and mainly involved in the head and neck area. The defining genetic hallmark on these tumors is that testis-specific nuclear gene (NUTM1) fuses to bromodomain protein family member 4 gene (BRD4), resulting in the formation of BRD4-NUTM1 transcript. Here, we report a case with myeloid neoplasm complicating with eosinophilia (MLN-Eo) and rearrangement of PDGFRA, which co-exists with a new nucleosome assemble protein 1–like 4 gene (NAP1L4) NAP1L4-NUTM1 fusion. The patient have unusually clinical features and therapeutic reaction to imatinib mesylate. The cloned NAP1L4-NUTM1 gene structure is also determined.

NUT 中线癌 (NMC) 是一种侵袭性肿瘤，主要累及头颈部区域。这些肿瘤的定义遗传标志是睾丸特异性核基因 ( NUTM1 ) 与溴结构域蛋白家族成员 4 基因 ( BRD4 )融合，从而形成BRD4-NUTM1转录物。在这里，我们报告了一例骨髓肿瘤并发嗜酸性粒细胞增多症 (MLN-Eo) 和PDGFRA重排的病例，该病例与新的核小体组装蛋白 1 样 4 基因 ( NAP1L4 ) NAP1L4-NUTM1融合共存。患者对甲磺酸伊马替尼有异常的临床特征和治疗反应。克隆的NAP1L4-NUTM1 基因结构也被确定。