Neuroprotective activities of bacopa, lycopene, astaxanthin, and vitamin B12 combination on oxidative stress-dependent neuronal death.,Journal of Cellular Biochemistry

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Neuroprotective activities of bacopa, lycopene, astaxanthin, and vitamin B12 combination on oxidative stress-dependent neuronal death.
Journal of Cellular Biochemistry ( IF 3.0 ) Pub Date : 2020-05-25 , DOI: 10.1002/jcb.29722
Vanessa Castelli ₁ , Francesco Melani ₂ , Claudio Ferri ₁ , Michele d'Angelo ₁ , Mariano Catanesi ₁ , Davide Grassi ₁ , Elisabetta Benedetti ₁ , Antonio Giordano _{3,

4} , Annamaria Cimini _{1,

3} , Giovambattista Desideri ₁

Affiliation

Oxidative stress is considered the common effector of the cascade of degenerative events in many neurological conditions. Thus, in this paper we tested different nutraceuticals in H₂O₂ in vitro model to understand if could represent an adjuvant treatment for neurological diseases. In this study, nutraceuticals bacopa, lycopene, astaxanthin, and vitamin B12 were used alone or in combination in human neuronal differentiated SH‐SY5Y cells upon hydrogen peroxide‐induced injury and neuroprotective, neuronal death pathways were analyzed. The nutraceuticals analyzed were able to protect H₂O₂ cytotoxic effects, through increasing cell viability and proteins involved in neuroprotection pathways and restoring proteins involved in cell death pathways. On this basis, it is possible to propose the use of these compounds as dietary supplement for the prevention or as adjuvant to the only symptomatic treatments so far available for neurodegenerative diseases.

中文翻译：

假马齿苋、番茄红素、虾青素和维生素 B12 组合对氧化应激依赖性神经元死亡的神经保护活性。

氧化应激被认为是许多神经系统退行性事件级联的常见效应器。因此，在本文中，我们在 H ₂ O ₂体外模型中测试了不同的营养保健品，以了解是否可以代表神经系统疾病的辅助治疗。在这项研究中，营养保健品假马齿苋、番茄红素、虾青素和维生素 B12 单独或联合使用在人神经元分化的 SH-SY5Y 细胞中，对过氧化氢诱导的损伤和神经保护、神经元死亡途径进行了分析。分析的营养制品能够通过增加细胞活力和参与神经保护途径的蛋白质以及恢复参与细胞死亡途径的蛋白质来保护 H ₂ O _{2细胞毒性作用。}在此基础上，可以建议使用这些化合物作为预防神经退行性疾病的膳食补充剂或作为迄今为止可用于神经退行性疾病的唯一对症治疗的辅助剂。

更新日期：2020-05-25

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