Nanodelivery Systems for Topical Management of Skin Disorders,Molecular Pharmaceutics

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Nanodelivery Systems for Topical Management of Skin Disorders
Molecular Pharmaceutics ( IF 4.5 ) Pub Date : 2020-05-29 , DOI: 10.1021/acs.molpharmaceut.0c00154
Mingyue Cui ₁ , Christian Wiraja ₁ , Sharon Wan Ting Chew ₁ , Chenjie Xu _{1,

2,

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Affiliation

Topical drug delivery has inherent advantages over other administration routes. However, the existence of stratum corneum limits the diffusion to small and lipophilic drugs. Fortunately, the advancement of nanotechnology brings along opportunities to address this challenge. Taking the unique features in size and surface chemistry, nanocarriers such as liposomes, polymeric nanoparticles, gold nanoparticles, and framework nucleic acids have been used to bring drugs across the skin barrier to epidermis and dermis layers. This article reviews the development of these formulations and focuses on their applications in the treatment of skin disorders such as acne, skin inflammation, skin infection, and wound healing. Existing hurdles and further developments are also discussed.

中文翻译：

用于皮肤病局部治疗的纳米递送系统

局部给药具有优于其他给药途径的固有优势。然而，角质层的存在限制了向小分子和亲脂性药物的扩散。幸运的是，纳米技术的进步带来了应对这一挑战的机会。凭借其在尺寸和表面化学方面的独特特性，脂质体、聚合物纳米颗粒、金纳米颗粒和框架核酸等纳米载体已被用于将药物穿过皮肤屏障到达表皮和真皮层。本文回顾了这些配方的发展，并重点介绍了它们在治疗皮肤疾病（如痤疮、皮肤炎症、皮肤感染和伤口愈合）中的应用。还讨论了现有的障碍和进一步的发展。

更新日期：2020-05-29

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