Background: Transcranial Direct Current Stimulation (tDCS) is a technique where a weak current is passed through the electrodes placed on the scalp. The distribution of the electric current induced in the brain due to tDCS is provided by simulation toolbox like Realistic-volumetric-Approach-based-Simulator-for-Transcranial-electric-stimulation (ROAST). However, the procedure to estimate the total current density induced at the target and the intermediary region of the cortex is complex. The Systematic-Approach-for-tDCS-Analysis (SATA) was developed to overcome this problem. However, SATA is limited to standardized headspace only. Here we develop individual-SATA (i-SATA) to extend it to individual head. Method: T1-weighted images of 15 subjects were taken from two Magnetic Resonance Imaging (MRI) scanners of different strengths. Across the subjects, the montages were simulated in ROAST. i-SATA converts the ROAST output to Talairach space. The x, y and z coordinates of the anterior commissure (AC), posterior commissure (PC), and Mid-Sagittal (MS) points are necessary for the conversion. AC and PC are detected using the acpcdetect toolbox. We developed a method to determine the MS in the image and cross-verified its location manually using BrainSight. Result: Determination of points with i-SATA is fast and accurate. The i-SATA provided estimates of the current-density induced across an individuals cortical lobes and gyri as tested on images from two different scanners. Conclusion: Researchers can use i-SATA for customizing tDCS-montages. With i-SATA it is also easier to compute the inter-individual variation in current-density across the target and intermediary regions of the brain. The software is publicly available.

中文翻译：

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SATA-SATA：一种基于MATLAB的工具箱，用于估计由单个大脑中经颅直流电刺激产生的电流密度

背景技术：经颅直流电刺激（tDCS）是一种使微弱的电流流经置于头皮上的电极的技术。由tDCS引起的在大脑中感应的电流分布由仿真工具箱提供，如基于现实体积法的经颅电刺激模拟器（ROAST）。但是，估算皮层的目标和中间区域感应的总电流密度的过程很复杂。开发用于tDCS分析的系统方法（SATA）来解决此问题。但是，SATA仅限于标准化的顶空。在这里，我们开发了单个SATA（i-SATA），以将其扩展到单个磁头。方法：从两个不同强度的磁共振成像（MRI）扫描仪上拍摄15位受试者的T1加权图像。跨学科，蒙太奇在ROAST中进行了模拟。i-SATA将ROAST输出转换为Talairach空间。转换需要前连合（AC），后连合（PC）和矢状中（MS）点的x，y和z坐标。使用acpcdetect工具箱检测交流电和PC。我们开发了一种确定图像中MS的方法，并使用BrainSight手动交叉验证了其位置。结果：使用i-SATA确定点快速而准确。i-SATA提供了对在两个不同扫描仪的图像上测试的单个皮层叶和回旋中所感应的电流密度的估计。结论：研究人员可以使用i-SATA定制tDCS剪辑。使用i-SATA，计算跨大脑目标区域和中间区域的电流密度的个体间差异也更加容易。