Due to the increasing safety concerns about the risk of spreading antibiotic resistance in the environment, and the presence of chemical residues in animal products, using organic acids (OAs) to replace antibiotic in the diet of farm animals has increased considerably in recent years. It has been suggested that OAs could attribute to diverse elements such as antimicrobial activity, decreasing the pH of digesta particularly in the gastrointestinal tract (GIT), slowing feed transit in the GIT to maximize feed digestion and nutrient absorption, inducing enzyme secretion and activity in the small intestine, and providing nutrients to intestinal tissue. It has been reported that OAs mixture might be more effective than individual OAs due to the synergistic effects of different pKa values and have a broad-spectrum activity. In conclusion, this review showed that an OA mixture, which can improve nutrient digestibility and growth performance, modulate intestinal bacterial populations and improve gut health, as well as decreasing gas emission, can be used as alternative to antibiotic growth promoters. However, the results of OA mixtures are not always consistent, and the response to dietary OAs could be affected by the type of OAs, dosage, feed formula, and the age of animals. In this review, we will give an overview of the current use of OAs mixture in swine feed.

中文翻译：

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有机酸混合物作为猪的饲料添加剂-综述。

由于越来越多的安全性考虑到在环境中传播抗生素耐药性的风险，以及动物产品中存在化学残留物，因此近年来在农场动物的饮食中使用有机酸（OAs）代替抗生素已大大增加。有人认为，OAs可以归因于多种因素，例如抗微生物活性，降低消化道的pH值，特别是在胃肠道（GIT）中，减缓GIT中的饲料运输以最大程度地提高饲料的消化和营养吸收，诱导酶的分泌和活性。小肠，并为肠组织提供营养。据报道，由于不同的pKa值具有协同作用，并且具有广谱活性，因此OAs混合物可能比单独的OAs更有效。结论，这篇评论表明，可以改善营养物质消化率和生长性能，调节肠道细菌种群，改善肠道健康以及减少气体排放的OA混合物可以用作抗生素生长促进剂的替代品。但是，OA混合物的结果并不总是一致的，对OA饮食的响应可能会受到OA类型，剂量，饲料配方和动物年龄的影响。在这篇评论中，我们将概述目前在猪饲料中使用OAs混合物的情况。OA的类型，剂量，饲料配方和动物年龄可能会影响对膳食OA的反应。在这篇评论中，我们将概述目前在猪饲料中使用OAs混合物的情况。OA的类型，剂量，饲料配方和动物年龄可能会影响对膳食OA的反应。在这篇综述中，我们将概述目前在猪饲料中使用OAs混合物的情况。