Gut–organ axis: A microbial outreach and networking,Letters in Applied Microbiology

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Gut–organ axis: A microbial outreach and networking
Letters in Applied Microbiology ( IF 2.0 ) Pub Date : 2020-07-16 , DOI: 10.1111/lam.13333
S Ahlawat ₁ , Asha ₁ , K K Sharma ₁

Affiliation

Human gut microbiota (GM) includes a complex and dynamic population of microorganisms that are crucial for well-being and survival of the organism. It has been reported as diverse and relatively stable with shared core microbiota, including Bacteroidetes and Firmicutes as the major dominants. They are the key regulators of body homeostasis, involving both intestinal and extra-intestinal effects by influencing many physiological functions such as metabolism, maintenance of barrier homeostasis, inflammation, and hematopoiesis. Any alteration in GM community structures not only trigger gut disorders, but also influence other organs and cause associated diseases. In recent past, the GM has been defined as a "vital organ" with its involvement with other organs; thus, establishing a link or a bi- or multi-directional communication axis between the organs via neural, endocrine, immune, humoral, and metabolic pathways. Alterations in GM have been linked to several diseases known to humans; although the exact interaction mechanism between the gut and the organs is yet to be defined. In this review, the bi-directional relationship between the gut and the vital human organs was envisaged and discussed under several headings. Furthermore, several disease symptoms were also re-visited to re-define the communication network between the gut microbes and the associated organs.

中文翻译：

肠道-器官轴：微生物外展和网络

人类肠道微生物群 (GM) 包括复杂且动态的微生物群，它们对生物体的健康和生存至关重要。据报道，它具有多样性和相对稳定的共享核心微生物群，包括拟杆菌门和厚壁菌门作为主要优势。它们是体内平衡的关键调节剂，通过影响许多生理功能，如代谢、维持屏障稳态、炎症和造血，涉及肠道和肠外效应。转基因社区结构的任何改变不仅会引发肠道疾病，还会影响其他器官并导致相关疾病。最近，转基因被定义为与其他器官有关的“重要器官”；因此，通过神经、内分泌、免疫、体液和代谢途径在器官之间建立联系或双向或多向通信轴。转基因的改变与人类已知的几种疾病有关。尽管肠道和器官之间的确切相互作用机制尚未确定。在这篇综述中，肠道和重要人体器官之间的双向关系在几个标题下进行了设想和讨论。此外，还重新审视了几种疾病症状，以重新定义肠道微生物与相关器官之间的通信网络。在这篇综述中，肠道和重要人体器官之间的双向关系在几个标题下进行了设想和讨论。此外，还重新审视了几种疾病症状，以重新定义肠道微生物与相关器官之间的通信网络。在这篇综述中，肠道和重要人体器官之间的双向关系在几个标题下进行了设想和讨论。此外，还重新审视了几种疾病症状，以重新定义肠道微生物与相关器官之间的通信网络。

更新日期：2020-07-16

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