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Enhancers, development, and evolution.
Development, Growth & Differentiation ( IF 1.7 ) Pub Date : 2020-05-29 , DOI: 10.1111/dgd.12683 Atsushi Kuroiwa 1
Development, Growth & Differentiation ( IF 1.7 ) Pub Date : 2020-05-29 , DOI: 10.1111/dgd.12683 Atsushi Kuroiwa 1
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A single‐celled fertilized egg develops into a complex, multicellular animal through a series of selection processes of developmental pathways. During these processes, regulatory genes exhibit spatiotemporally restricted expression under the control of the species‐specific genetic program, and dictate developmental processes from germ layer formation to cellular differentiation. Elucidation of molecular mechanisms underlying developmental processes and also of mechanistic bases for morphological diversification during evolution is one of the central issues in contemporary developmental biology. Progress has been made due to recent technological innovations, such as high‐throughput nucleotide sequencing, live‐cell imaging, efficient genetic manipulation, and establishment of the organoid system, opening new avenues to the above issues.
中文翻译：
增强器，开发和演进。
通过一系列发育途径的选择过程，单细胞受精卵发育成复杂的多细胞动物。在这些过程中，调节基因在物种特异性遗传程序的控制下表现出时空受限的表达，并指示从胚层形成到细胞分化的发育过程。阐明发育过程的分子机制以及进化过程中形态多样化的机制基础是当代发育生物学的中心问题之一。由于最近的技术创新，例如高通量核苷酸测序，活细胞成像，有效的遗传操作和类器官系统的建立，已经取得了进展，为上述问题开辟了新途径。
更新日期：2020-06-29
中文翻译：
增强器，开发和演进。
通过一系列发育途径的选择过程，单细胞受精卵发育成复杂的多细胞动物。在这些过程中，调节基因在物种特异性遗传程序的控制下表现出时空受限的表达，并指示从胚层形成到细胞分化的发育过程。阐明发育过程的分子机制以及进化过程中形态多样化的机制基础是当代发育生物学的中心问题之一。由于最近的技术创新，例如高通量核苷酸测序，活细胞成像，有效的遗传操作和类器官系统的建立，已经取得了进展，为上述问题开辟了新途径。
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