A TOMM40/APOE allele encoding APOE-E3 predicts high likelihood of late-onset Alzheimer's disease in autopsy cases.,Molecular Genetics & Genomic Medicine

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A TOMM40/APOE allele encoding APOE-E3 predicts high likelihood of late-onset Alzheimer's disease in autopsy cases.
Molecular Genetics & Genomic Medicine ( IF 1.5 ) Pub Date : 2020-05-30 , DOI: 10.1002/mgg3.1317
Selma M Soyal ₁ , Markus Kwik ₁ , Ognian Kalev ₂ , Stefan Lenz ₂ , Greta Zara ₁ , Peter Strasser ₃ , Wolfgang Patsch ₁ , Serge Weis ₂

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The APOE‐ε4 allele is an established risk factor for Alzheimer's disease (AD). TOMM40 located adjacent to APOE has also been implicated in AD but reports of TOMM40 associations with AD that are independent of APOE‐ε4 are at variance.

中文翻译：

在尸检病例中，编码 APOE-E3 的 TOMM40/APOE 等位基因预测迟发性阿尔茨海默病的可能性很高。

APOE ‐ε4 等位基因是阿尔茨海默病 (AD) 的既定危险因素。位于APOE附近的TOMM40也与 AD 相关，但有关TOMM40与 AD 关联且独立于APOE ‐ε4 的报道存在差异。

更新日期：2020-05-30

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