Increased Lipophilicity of Halogenated Ruthenium(II) Polypyridyl Complexes Leads to Decreased Phototoxicity in vitro when Used as Photosensitizers for Photodynamic Therapy.,ChemBioChem

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Increased Lipophilicity of Halogenated Ruthenium(II) Polypyridyl Complexes Leads to Decreased Phototoxicity in vitro when Used as Photosensitizers for Photodynamic Therapy.
ChemBioChem ( IF 2.6 ) Pub Date : 2020-05-30 , DOI: 10.1002/cbic.202000289
Saonli Roy ₁ , Elisa Colombo ₁ , Robin Vinck ₂ , Cristina Mari ₁ , Riccardo Rubbiani ₁ , Malay Patra ₃ , Gilles Gasser ₂

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One up, one down: Ru^II polypyridyl complexes are prime candidates for the development of new photosensitizers for photodynamic therapy. Increasing their lipophilicity could result in improved pharmacological properties. The relationship between lipophilicity and in vitro phototoxicity of halogenated Ru^II complexes was investigated.