Metformin mitigates gastrointestinal radiotoxicity and radiosensitises P53 mutation colorectal tumours via optimising autophagy.,British Journal of Pharmacology

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Metformin mitigates gastrointestinal radiotoxicity and radiosensitises P53 mutation colorectal tumours via optimising autophagy.
British Journal of Pharmacology ( IF 6.8 ) Pub Date : 2020-05-30 , DOI: 10.1111/bph.15149
Long Chen ₁ , Fengying Liao ₁ , Zhongyong Jiang ₁ , Chi Zhang ₁ , Ziwen Wang ₁ , Peng Luo ₁ , Qingzhi Jiang _{1,

2} , Jie Wu ₁ , Qing Wang _{1,

2} , Min Luo _{1,

3} , Xueru Li ₄ , Yu Leng ₄ , Le Ma ₁ , Gufang Shen ₁ , Zelin Chen ₁ , Yu Wang ₁ , Xu Tan ₁ , Yibo Gan ₁ , Dengqun Liu ₁ , Yunsheng Liu ₁ , Chunmeng Shi ₁

Affiliation

There is an urgent but unmet need for mitigating radiation‐induced intestinal toxicity while radio sensitising tumours for abdominal radiotherapy. We aimed to investigate the effects of metformin on radiation‐induced intestinal toxicity and radiosensitivity of colorectal tumours.

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