In this communication the isolation, chemical and physiological characterization of three new toxins from the scorpion Centruroides baergi are reported. Their immunoreactive properties with scFvs generated in our group are described. The three new peptides, named Cb1, Cb2 and Cb3 affect voltage-dependent Na⁺ channels in a differential manner. These characteristics, explain the toxicity of this venom. Molecular interactions in real-time among these toxins and the best recombinant antibodies generated in our group, revealed that one of them was able to neutralize the main toxin of this venom (Cb1). These results represent an important advance for the neutralization of this venom and serve as the basis for generating new scFvs that will allow the neutralization of similar toxins from other venoms that have no yet been neutralized.

在该通报中，报道了来自蝎形变种Certrouroides baergi的三种新毒素的分离，化学和生理学表征。描述了他们与我们小组中产生的scFvs的免疫反应特性。三种新肽，分别称为Cb1，Cb2和Cb3，会影响电压依赖性Na ⁺通道以差分方式。这些特征解释了这种毒液的毒性。这些毒素与我们小组中产生的最佳重组抗体之间的实时分子相互作用表明，其中一种能够中和该毒液的主要毒素（Cb1）。这些结果代表了中和该毒液的重要进展，并为产生新的scFv奠定了基础，新的scFv可以中和尚未被中和的其他毒液中的相似毒素。