Generation of two non-integrated induced pluripotent stem cell lines from urine-derived cells of a Chinese patient carrying NF1 gene mutation.,Stem Cell Research

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Generation of two non-integrated induced pluripotent stem cell lines from urine-derived cells of a Chinese patient carrying NF1 gene mutation.
Stem Cell Research ( IF 0.8 ) Pub Date : 2020-05-30 , DOI: 10.1016/j.scr.2020.101842
Liang Shi ₁ , Yazhou Cui ₁ , Zijuan Qi ₂ , Xiaoyan Zhou ₁ , Jing Luan ₁ , Jinxiang Han ₁

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Mutations in the neurofibromin (NF1) gene cause neurofibromatosis type 1 (NF1), a complex tumour predisposition syndrome. Here, we generated two induced pluripotent stem cell (iPSC) lines using urine cells (UCs) derived from a 21-year-old female NF1 patient carrying c.496_497delGT mutation in the NF1 gene (p.Val166LeufsTer7). The newly derived SMBCi003-A and SMBCi003-B iPSC lines used as a cellular model to unravel pathogenesis of NF1.

更新日期：2020-05-30

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