Enantioselectivity effects of imazethapyr enantiomers to metabolic responses in mice,Pesticide Biochemistry and Physiology

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Enantioselectivity effects of imazethapyr enantiomers to metabolic responses in mice
Pesticide Biochemistry and Physiology ( IF 4.2 ) Pub Date : 2020-09-01 , DOI: 10.1016/j.pestbp.2020.104619
Chenyang Yao ₁ , Jing Sheng ₁ , Sen Yan ₂ , Sinuo Tian ₂ , Zhiyuan Meng ₂ , Zhiqiang Zhou ₂ , Wentao Zhu ₂

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Imazethapyr (IMZT) is a typical chiral pesticide with two enantiomers with the R-IMZT having the main herbicidal activity. However, the enantioselectivity of the effects of IMZT enantiomers on human and animals is still unclear. In this study, a nuclear magnetic resonance (NMR)-based metabolomics method and determination of oxidative stress were used to evaluate the enantioselectivity of IMZT enantiomers in mice. The results showed that the R-IMZT caused larger disturbances of endogenous metabolites and the S-IMZT had stronger interferences to oxidation defense system. The significantly perturbed metabolic pathways in mice exposed to the R-enantiomer were the valine, leucine and isoleucine biosynthesis pathway as well as the phenylalanine, tyrosine and tryptophan biosynthesis pathway. However, exposure of mice to the S-enantiomer did not significantly affect the metabolic pathways, but exposure led to an increase of catalase (CAT) activity and an increase in malondialdehyde (MDA) content in the liver. These results indicate that we need to conduct a more comprehensive assessment of the health risks of pesticide monomers in the future. In a word, these results provide more evidence for assessing the differences in health risks of IMZT enantiomers to mammals as well as provide more references for the promotion and use of pesticide monomers in the future.

中文翻译：

咪唑乙烟酸对映异构体对小鼠代谢反应的对映选择性影响

咪草烟 (IMZT) 是一种典型的手性农药，具有两种对映异构体，其中 R-IMZT 具有主要的除草活性。然而，IMZT 对映异构体对人和动物的影响的对映选择性仍不清楚。在这项研究中，基于核磁共振 (NMR) 的代谢组学方法和氧化应激的测定用于评估 IMZT 对映异构体在小鼠中的对映选择性。结果表明，R-IMZT对内源性代谢物的干扰较大，S-IMZT对氧化防御系统有较强的干扰。暴露于 R 对映体的小鼠的代谢途径显着紊乱是缬氨酸、亮氨酸和异亮氨酸生物合成途径以及苯丙氨酸、酪氨酸和色氨酸生物合成途径。然而，小鼠暴露于 S-对映体并没有显着影响代谢途径，但暴露导致过氧化氢酶 (CAT) 活性增加和肝脏中丙二醛 (MDA) 含量增加。这些结果表明，我们未来需要对农药单体的健康风险进行更全面的评估。总之，这些结果为评估IMZT对映体对哺乳动物健康风险的差异提供了更多的证据，也为今后农药单体的推广和使用提供了更多的参考。这些结果表明，我们未来需要对农药单体的健康风险进行更全面的评估。总之，这些结果为评估IMZT对映体对哺乳动物健康风险的差异提供了更多的证据，也为今后农药单体的推广和使用提供了更多的参考。这些结果表明，我们未来需要对农药单体的健康风险进行更全面的评估。总之，这些结果为评估IMZT对映体对哺乳动物健康风险的差异提供了更多的证据，也为今后农药单体的推广和使用提供了更多的参考。

更新日期：2020-09-01

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