Post-stroke cognitive impairment (PSCI) is a severe complication of stroke. Predicting PSCI is difficult because some risk factors for stroke, such as blood glucose level and blood pressure, are affected by many other elements. Although recent studies have shown that high serum uric acid (UA) levels are associated with cognitive dysfunction and may be a risk factor for PSCI, its impact remains unclear. Accordingly, the present study aimed to explore the association between serum UA level and PSCI. In total, 274 patients who experienced acute cerebral infarction, confirmed between January 2016 and December 2018, were enrolled. Baseline data and biological indicators were recorded. According to the Montreal Cognitive Assessment (MoCA) scores, patients were divided into two groups: PSCI and non-PSCI. Logistic regression analysis was used to determine possible risk factors for PSCI. Results demonstrated that serum UA levels were significantly higher in the PSCI group than in the non-PSCI group. Multivariable logistic analysis revealed that age, years of education, and UA level were independent risk factors for PSCI. PSCI patients were subdivided according to serum UA level: high and low. Hypertension history and homocysteine (Hcy) levels differed significantly between the high and low UA level groups. Further analysis revealed that a history of hypertension and Hcy demonstrated a certain correlation (r = 0.163, 0.162; P < 0.05), suggesting that serum UA level was an independent risk factor for PSCI. These findings indicate that serum UA level was correlated with PSCI in post-stroke patients and is anticipated to be used in clinical practice to reduce the incidence of PSCI.

中风后认知障碍（PSCI）是中风的严重并发症。由于某些中风的危险因素，例如血糖水平和血压，受许多其他因素的影响，因此很难预测PSCI。尽管最近的研究表明，高血清尿酸（UA）水平与认知功能障碍有关，可能是PSCI的危险因素，但其影响尚不清楚。因此，本研究旨在探讨血清UA水平与PSCI之间的关系。总共入选了2016年1月至2018年12月期间确诊的274例急性脑梗死患者。记录基线数据和生物学指标。根据蒙特利尔认知评估（MoCA）评分，将患者分为两组：PSCI和非PSCI。Logistic回归分析用于确定PSCI的可能危险因素。结果表明，PSCI组的血清UA水平显着高于非PSCI组。多变量逻辑分析表明，年龄，受教育年限和UA水平是PSCI的独立危险因素。根据血清UA水平将PSCI患者细分为：高和低。高和低UA水平组之间的高血压病史和高半胱氨酸（Hcy）水平存在显着差异。进一步的分析表明，高血压和Hcy的病史显示出一定的相关性（r = 0.163，0.162; 和UA水平是PSCI的独立危险因素。根据血清UA水平将PSCI患者细分为：高和低。高和低UA水平组之间的高血压病史和高半胱氨酸（Hcy）水平存在显着差异。进一步的分析表明，高血压和Hcy的病史显示出一定的相关性（r = 0.163，0.162; 和UA水平是PSCI的独立危险因素。根据血清UA水平将PSCI患者细分为：高和低。高和低UA水平组之间的高血压病史和高半胱氨酸（Hcy）水平存在显着差异。进一步的分析表明，高血压和Hcy的病史显示出一定的相关性（r = 0.163，0.162;P  <0.05），表明血清UA水平是PSCI的独立危险因素。这些发现表明中风后患者的血清UA水平与PSCI相关，并有望在临床实践中用于降低PSCI的发生率。