INTRODUCTION The role of metabolically unhealthy (MU) overweight in influencing stroke prognosis has not been fully assessed and conclusive data about the impact of sex are lacking. Aim of this study was to evaluate the possible correlations among MU overweight, sex and ischemic stroke severity and outcome. METHODS All consecutive patients with acute non-lacunar ischemic stroke observed over a one-year period were considered. MU subjects were selected and classified according to the body mass index (BMI) values. The relationships among sex, BMI and National Institutes of Health Stroke Scale (NIHSS) score at admission and modified Rankin scale (mRS) score at discharge were analysed with multivariate models. RESULTS 180 patients were included. A significantly increasing trend in the NIHSS (p = .030) and in the mRS (p = .001) scores along with the increase of the BMI category was detected in women. Men showed a significantly decreasing trend in the NIHSS (p = .040) and a non-significant decreasing trend in the mRS (p = .290) scores with increasing BMI category. CONCLUSIONS Our findings show that sex can influence stroke severity and outcome among MU patients. The worse outcome observed in women suggest the need of considering differential sex-based clinical approaches in stroke overweight patients.

中文翻译：

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性别对代谢不健康超重患者缺血性卒中严重程度和结局的影响

介绍 代谢不健康 (MU) 超重在影响卒中预后方面的作用尚未得到充分评估，并且缺乏关于性别影响的结论性数据。本研究的目的是评估 MU 超重、性别和缺血性卒中严重程度和结果之间可能的相关性。方法 考虑了一年内观察到的所有连续的急性非腔隙性缺血性卒中患者。根据体重指数 (BMI) 值选择和分类 MU 受试者。采用多元模型分析性别、BMI、入院时美国国立卫生研究院卒中量表（NIHSS）评分与出院时改良Rankin量表（mRS）评分之间的关​​系。结果 包括 180 名患者。NIHSS (p = .030) 和 mRS (p = .030) 的显着增加趋势。001) 分数随着 BMI 类别的增加在女性中被检测到。随着 BMI 类别的增加，男性的 NIHSS (p = .040) 呈显着下降趋势，而 mRS (p = .290) 得分呈非显着下降趋势。结论 我们的研究结果表明，性别可以影响 MU 患者的卒中严重程度和结果。在女性中观察到的更糟糕的结果表明需要考虑针对中风超重患者的不同的基于性别的临床方法。