Preserved eggs are a type of egg products made from duck eggs and have anti-inflammatory activity. The purpose of this study was to investigate the effects of preserved egg simulated gastrointestinal digests on the apoptosis of HT29 and HepG2 cells. The cells morphology, apoptosis and apoptosis associated genes (Bcl-2, Bax, COX-2) and proteins (caspase-3 and caspase-9) were evaluated. The results showed that preserved egg digests significantly up regulated the expression of genes Bax, caspase-3 and caspase-9, which are involved in cell apoptosis, and up regulated the expression of the pro-apoptotic factors Bcl-2 and COX-2 both in HT29 and HepG2 cells, leading to a reduction in the ratio of Bcl-2:Bax proteins. The results also showed that the apoptosis of HT29 and HepG2 cells was promoted by the PED in a dose-dependent manner. Thus, PED may serve as a potential functional food for cancer treatment.

皮蛋是由鸭蛋制成的一种蛋制品，具有抗炎作用。这项研究的目的是调查保存的鸡蛋模拟胃肠道消化物对HT29和HepG2细胞凋亡的影响。评估了细胞形态，凋亡和凋亡相关基因（Bcl-2，Bax，COX-2）和蛋白质（caspase-3和caspase-9）。结果显示，保存的卵消化物显着上调了与细胞凋亡有关的基因Bax，caspase-3和caspase-9的表达，并上调了促凋亡因子Bcl-2和COX-2的表达。在HT29和HepG2细胞中，Bcl-2：Bax蛋白的比例降低。结果还表明，PED以剂量依赖的方式促进了HT29和HepG2细胞的凋亡。从而，