OBJECTIVE To quantitate left ventricular mass index (LVMI) and correlate it with inflammation, insulin resistance (IR) and serum androgen levels among nonobese normotensive women with polycystic ovary syndrome (PCOS). DESIGN Cross-sectional study SETTING: Tertiary care institute in North India PATIENTS: A total of 260 drug-naive women qualifying the Rotterdam 2003 criteria for diagnosis of PCOS and 250 apparently healthy women matched for age and body mass index (BMI). INTERVENTIONS Clinical, biochemical, hormonal, and inflammatory marker assessment was followed by estimation of LVM and LVMI by 2-dimensional echocardiography. MAIN OUTCOME MEASURES LVM and LVMI in nonobese, normotensive women with PCOS and its correlation with subinflammation, IR, and androgen excess. RESULTS Mean ages (28.08 ± 4.18 vs. 29.44 ± 6.33 years) and BMI (24.43 ± 4.15 vs. 23.92 ± 4.21 kg/m2) of cases vs. controls were comparable, as was blood pressure and plasma glucose (1 hour after oral glucose tolerance test [OGTT]). Women with PCOS had fewer menstrual cycles per year and higher Ferriman-Gallwey scores, plasma insulin, homeostasis model assessment of IR, total testosterone, plasma glucose (fasting and 2 hours after OGTT), serum high-sensitive C-reactive protein, tumor necrosis factor-α, and interleukin-6 than did the controls (P<.001). Significant differences were observed in LVM (101.50 ± 30.19 vs. 89.35 ± 27.57 g) and LVMI (63.60 ± 16.67 vs. 56.32 ± 10.84 g/m2) between women with PCOS and the controls (P<.001). Multivariate analysis revealed that proinflammatory markers and IR rather than hyperandrogenism correlated with LVMI. CONCLUSION We conclude that normotensive nonobese women with PCOS were more likely to have elevated mean LVMI than were healthy controls and it was positively correlated with proinflammatory markers and IR but not with androgen excess. Well-designed long-term follow-up studies with a larger cohort of subjects with comprehensive cardiovascular risk assessment are warranted to conclusively answer the question.

中文翻译：

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左心室心肌质量指数及其作为非肥胖、血压正常的多囊卵巢综合征印度女性心血管风险早期标志物的相关性：横断面研究的经验教训

目的 量化左心室质量指数 (LVMI) 并将其与多囊卵巢综合征 (PCOS) 的非肥胖正常血压女性的炎症、胰岛素抵抗 (IR) 和血清雄激素水平相关联。设计 横断面研究 地点：北印度的三级保健机构 患者：共有 260 名符合鹿特丹 2003 年 PCOS 诊断标准的未吸毒女性和 250 名年龄和体重指数 (BMI) 相匹配的明显健康女性。干预 临床、生化、激素和炎症标志物评估之后，通过二维超声心动图估计 LVM 和 LVMI。主要结局指标 非肥胖、血压正常的 PCOS 女性的 LVM 和 LVMI 及其与亚炎症、IR 和雄激素过多的相关性。结果 平均年龄（28.08 ± 4.18 对 29.44 ± 6.33 岁）和 BMI（24.43 ± 4.15 对 23.92 ± 4.21 kg/m2) 的病例与对照组具有可比性，血压和血浆葡萄糖也是如此（口服葡萄糖耐量试验 [OGTT] 后 1 小时）。患有 PCOS 的女性每年的月经周期更少，Ferriman-Gallwey 评分、血浆胰岛素、IR 稳态模型评估、总睾酮、血糖（禁食和 OGTT 后 2 小时）、血清高敏 C 反应蛋白、肿瘤坏死率更高因子-α 和白细胞介素-6 与对照组相比（P <.001）。在患有 PCOS 的女性和对照组之间观察到 LVM（101.50 ± 30.19 对 89.35 ± 27.57 g）和 LVMI（63.60 ± 16.67 对 56.32 ± 10.84 g/m2）的显着差异（P <.001）。多变量分析显示，促炎标志物和 IR 而不是雄激素过多症与 LVMI 相关。结论 我们得出结论，患有 PCOS 的血压正常的非肥胖女性比健康对照更有可能出现平均 LVMI 升高，并且它与促炎标志物和 IR 呈正相关，但与雄激素过多无关。设计良好的长期随访研究有必要对更大的受试者进行全面的心血管风险评估，以最终回答这个问题。