High cerebrospinal fluid (CSF) concentrations of the chemokine CXCL13 have been associated with Lyme neuroborreliosis (LNB), and have recently been studied as a potential diagnostic marker. It has proven difficult to establish a reliable diagnostic cut-off, possibly in part due to heterogenicity of case–control groups. Our purpose was to investigate CSF CXCL13 concentrations in patients with similar clinical presentations, facial palsy. We retrospectively included patients with facial palsy associated with LNB (n = 21), or varicella zoster virus (VZV) (n = 26). Median CXCL13 concentrations were significantly higher in patients with LNB facial palsy compared to VZV facial palsy. Receiver-operating characteristic analyses yielded an optimal cut-off concentration at 34.5 pg/mL (sensitivity 85.7%, specificity of 84.6%), lower than that in previous studies. Although the analysis has potential, it is still not adequately established that CXCL13 provides additional, clinically useful, diagnostic information over current recommendations.

趋化因子 CXCL13 的高脑脊液 (CSF) 浓度与莱姆神经疏螺旋体病 (LNB) 相关，最近已被研究作为潜在的诊断标志物。已证明很难建立可靠的诊断临界值，部分原因可能是病例对照组的异质性。我们的目的是调查具有相似临床表现、面瘫的患者的脑脊液 CXCL13 浓度。我们回顾性地纳入了与 LNB ( n  = 21) 或水痘带状疱疹病毒 (VZV) ( n = 26）。与 VZV 面瘫患者相比，LNB 面瘫患者的中位 CXCL13 浓度显着更高。接受者操作特征分析得出的最佳临界浓度为 34.5 pg/mL（灵敏度 85.7%，特异性 84.6%），低于之前的研究。尽管该分析具有潜力，但仍未充分确定 CXCL13 提供了比当前建议更多的临床有用的诊断信息。