Molecules and cellular processes important for nervous system development can be repurposed in adulthood for the regulation of adult neurogenesis, synaptic plasticity, and neural regeneration following injury or degeneration. Efforts to recapitulate neural development in order to ameliorate injury or disease are promising, but these often fall short of functional restoration due in part to our incomplete understanding of how these damaged circuits initially developed. Despite these limitations, such strategies provide hope that harnessing developmental mechanisms can restore nervous system functions following damage or disease.

中文翻译：

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重新利用成人神经系统的发育机制。

对神经系统发育重要的分子和细胞过程可以在成年后重新利用，以调节成人神经发生、突触可塑性以及损伤或退化后的神经再生。为了改善损伤或疾病而重现神经发育的努力是有希望的，但这些努力往往无法恢复功能，部分原因是我们对这些受损回路最初是如何发育的不完全了解。尽管存在这些限制，但此类策略提供了希望，即利用发育机制可以恢复损伤或疾病后的神经系统功能。