Babesia bigemina infection (also known as Texas fever) is reported as the most prevalent and main causative agent of bovine babesiosis, worldwide. The current study was undertaken to assess indicators of oxidative stress including activities of antioxidant enzymes and total antioxidant capacity (TAC), oxidation status of biomolecules and serum levels of trace elements as well as indicators of inflammation including sialic acid (SA) contents and cholinesterase activity in cattle naturally infected with B. bigemina. An infected group comprised of 20 crossbred Holstein cattle (3–4 years old) were diagnosed to be positive by both microscopy and nested PCR assay. The infected animals were subdivided into two groups according to their parasitemia rates (<20% and >20%). Furthermore, 10 healthy cattle were included as the control. The infection caused severe anemia in a parasitemia-burden dependent fashion. The activities of catalase and glucose-6-phosphate dehydrogenase as well as the levels of TAC, zinc, selenium, copper and manganese were significantly decreased as the parasitemia increased, accordingly. However, the activity of superoxide dismutase as well as the levels of malondialdehyde, protein carbonylation, DNA damage and iron, were significantly elevated in a parasitemeia-burden dependent manner. Additionally, glutathione peroxidase activity was significantly elevated with the lower rate of parasitemia, but the higher rate had no significant effect as compared to control. Moreover, total, protein and lipid binding SA contents were significantly increased but the activities of acetylcholinesterase and butyrylcholinesterase were significantly reduced, parasitemia dependently. Conclusively, the infection was remarkably associated with the induction of anemia, oxidative stress and inflammation.

据报道，二联巴贝虫感染（也称为德克萨斯热）是世界范围内牛巴贝虫病最流行和主要的病原体。目前的研究旨在评估氧化应激指标，包括抗氧化酶的活性和总抗氧化能力（TAC）、生物分子的氧化状态和血清微量元素水平，以及炎症指标，包括唾液酸（SA）含量和胆碱酯酶活性牛自然感染B. bigemina 。由 20 头杂交荷斯坦牛（3-4 岁）组成的感染组通过显微镜检查和巢式 PCR 检测均诊断为阳性。根据寄生虫血症率将感染动物分为两组（<20%和>20%）。此外，还包括10头健康牛作为对照。这种感染以寄生虫血症负担依赖性方式引起严重贫血。随着寄生虫血症的增加，过氧化氢酶和6-磷酸葡萄糖脱氢酶的活性以及TAC、锌、硒、铜和锰的水平均显着降低。然而，超氧化物歧化酶的活性以及丙二醛、蛋白质羰基化、DNA 损伤和铁的水平以寄生虫负荷依赖性方式显着升高。此外，随着寄生虫血症发生率的降低，谷胱甘肽过氧化物酶活性显着升高，但与对照相比，较高的比率没有显着影响。此外，总SA、蛋白质和脂质结合SA含量显着增加，但乙酰胆碱酯酶和丁酰胆碱酯酶的活性显着降低，与寄生虫血症相关。 总之，感染与贫血、氧化应激和炎症的诱发显着相关。