Equine theileriosis due to Theileria equi is probably the most widespread and pathogenic disease of equines, which comes with major cardiac and renal complications. This study was undertaken to investigate the biomarkers of cardiac and renal functions in horses infected with T. equi and determine the association between these parameters and the level of parasitemia. Giemsa-stained blood smears from 300 horses with ages of 3–4 years old were examined for detection of T. equi on erythrocytes. Moreover, multiplex PCR was employed for confirmation of the diagnosis in the 28 positive cases. Based on the rate of red blood cell infection, the infected animals were subdivided into horses with low (n = 9), moderate (n = 13) and high (n = 6) parasitemia. The concentrations of urea, creatinine, cystatin-C, cardiac troponin I (cTn-I), homocysteine (Hcy), myocardial fractions of creatine kinase (CK-MB) and d-dimer were determined in control (healthy) horses (n = 20) and the infected animals. The results revealed that both the renal (urea, creatinine and cystatin-C) and the cardiac (cTn-I, Hcy, CK-MB and d-dimer) biomarkers increased in a parasitemia burden-dependent pattern. However, urea, creatinine, cTn-I and d-dimer levels were not significantly influenced in the horses infected with low rate (<1 %) of parasitemia (p> 0.05). Moreover, all of the biomarkers were significantly and positively associated with the parasitemia (R²> 0.5). In conclusion, T. equi infection was related to cardiac and renal complications evidenced by increase in the levels of biomarkers and evaluation of these indices may have promise for early diagnosis of the complications.

由于马齿The泰勒虫（Theileria equi）引起的马胆脂化病可能是马类中最广泛，最致病的疾病，伴有主要的心脏和肾脏并发症。这项研究是调查的心脏和肾功能感染马的生物标志物T.球菌，并确定这些参数和原虫的水平之间的关联。检查了300匹3至4岁马的Giemsa染色血涂片，以检测马鞭草在红细胞上。此外，在28例阳性病例中，采用多重PCR确诊。根据红细胞感染率，将被感染的动物分为低（n = 9），中（n = 13）和高（n = 6）寄生虫病的马。在对照（健康）马匹中测定尿素，肌酐，半胱氨酸蛋白酶抑制剂C，心肌肌钙蛋白I（cTn-1），同型半胱氨酸（Hcy），肌酸激酶的心肌分数（CK-MB）和d-二聚体的浓度（n = 20）和被感染的动物。结果表明，肾脏（尿素，肌酐和半胱氨酸蛋白酶抑制剂-C）和心脏（cTn-1，Hcy，CK-MB和d-二聚体）生物标志物均以寄生虫负担依赖性模式增加。但是，尿素，肌酐，cTn-I和d在寄生虫血症发生率低（<1％）的马中，β-二聚体水平没有受到显着影响（p> 0.05）。此外，所有生物标志物均与寄生虫病呈显着正相关（R ² > 0.5）。总之，T。equi感染与心脏和肾脏并发症有关，这通过生物标志物水平的增加来证明，对这些指标的评估可能有望对并发症进行早期诊断。