The adverse health consequences of exposure to electromagnetic field emitted from cell phone has recently raised public concerns worldwide. Also, the Global System for Mobile Communications (GSM) standard that operates in 900 MHz frequency is the most popular. Therefore, we aimed to investigate the adverse effect of exposure to 900 MHz EMF (1 h/day) on the cerebella of 12-week-old rats. We also evaluated the protective activity of luteolin (20 μg/kg/day) against possible biological change in the cerebellar tissues exposed to EMF. Twenty-four male wistar albino rats were randomly assigned into four group of six rats: Control, EMF, EMF + luteolin, luteolin. Serological and biochemical analyses, as well as histopathological examination were performed on all cerebellar samples. We found that SOD (superoxide dismutase) level was significantly increased in the EMF group compared to the control group (p < 0.05). To the contrary, decreased SOD activity was detected in the EMF + luteolin group compared to control group (p < 0.05). The total number of Purkinje and granular cells was significantly decreased in the EMF group compared to the control group (p < 0.05). In the EMF + luteolin group, the total number of Purkinje and granular cells was significantly higher than the EMF group (p < 0.05). Histopathological evaluation also showed destructive damage to the architectures of cerebellar tissues. Our results suggest that exposure to EMF may cause cellular damage to the rat cerebellum. Further, the improvement of cerebellar damage may have resulted from antioxidant efficacy of luteolin by alleviating oxidative stress.

暴露于手机发出的电磁场对健康的不利影响最近引起了全世界公众的关注。此外，以 900 MHz 频率运行的全球移动通信系统 (GSM) 标准是最受欢迎的。因此，我们旨在研究暴露于 900 MHz EMF（1 小时/天）对 12 周龄大鼠小脑的不利影响。我们还评估了木犀草素（20 μg/kg/天）对暴露于 EMF 的小脑组织可能发生的生物变化的保护活性。二十四男性wistar白化病将大鼠随机分为四组，每组六只大鼠：对照组、EMF、EMF+木犀草素、木犀草素。对所有小脑样本进行血清学和生化分析以及组织病理学检查。我们发现与对照组相比，EMF 组的 SOD（超氧化物歧化酶）水平显着增加（p < 0.05）。相反，与对照组相比，在 EMF + 木犀草素组中检测到 SOD 活性降低 (p < 0.05)。与对照组相比，EMF 组的浦肯野细胞和颗粒细胞总数显着减少（p < 0.05）。在 EMF + 木犀草素组中，浦肯野和颗粒细胞总数显着高于 EMF 组（p < 0.05）。组织病理学评估还显示对小脑组织结构的破坏性损伤。我们的结果表明，暴露于 EMF 可能会对大鼠小脑造成细胞损伤。此外，木犀草素通过减轻氧化应激的抗氧化功效可能导致小脑损伤的改善。