Photothermal therapy (PTT) has gained tremendous interest as a mode of localized cancer therapy. Herein, we report a stable NIR absorbing gold modified dual responsive polymer core, chitosan-g-PNVCL (Au PNVCL NS). The in vitro studies reveal that Au PNVCL NS is a thermo-labile, non-immunogenic, biocompatible material possessing excellent photothermal transduction potential. The acute single-dose toxicity testing in mice reveals no abnormalities, indicating good tolerability of formulation. Au PNVCL NS shows excellent tumor ablation efficacy in vivo upon irradiation with 750 nm laser, thus improving the disease-free longevity of mice. Importantly, keeping our focus on the fate of this material, a significant surge of gold nanoparticles of size ~5 nm in the urine samples of treated mice assures rapid elimination of the material soon after PTT. These results, along with numerous gold nanoparticles deposition in the kidney of mice receiving PTT affirms the disintegrable nature of this nanoformulation while maintaining the desired PTT efficacy.

作为局部癌症治疗的一种模式，光热疗法（PTT）引起了极大的兴趣。在这里，我们报告稳定的近红外吸收金修饰双响应聚合物核心壳聚糖-g-PNVCL（Au PNVCL NS）。在体外研究表明，金PNVCL NS是热不稳定的，无免疫原性，生物相容性具有优良的光热转潜力的材料。在小鼠中进行的急性单剂量毒性试验未发现异常，表明制剂具有良好的耐受性。Au PNVCL NS在体内显示出优异的肿瘤消融功效在用750 nm激光照射时，可以提高小鼠的无病寿命。重要的是，我们一直关注这种材料的命运，在处理过的小鼠的尿液样本中，纳米粒子的大小约5 nm的大量增加，确保了PTT后很快消除了该材料。这些结果，以及在接受PTT的小鼠的肾脏中沉积的大量金纳米颗粒，证实了该纳米制剂的可崩解性，同时保持了所需的PTT功效。