Numerous eligible articles investigated the potential impact of the promoter region of UCP2 (rs659366) variant and the susceptibility for obesity with questionable outcomes. Our team designed this case–control combined with meta-analysis survey to illustrate the contribution of this variant with obesity. This case–control survey was formulated based on 110 obese Egyptian patients and 122 non-obese controls. Genomic DNA was amplified for ascertaining of UCP2 (G-866A; rs659366) variant exploiting the PCR–RFLP technique. A literature search was completed to investigate the involvement of this variant with obesity from various genetic databases. In this case–control study, the distribution of UCP2 (rs659366) variant showed a significant association with obesity among Egyptian subjects under allelic and dominant models (P value = 0.0006 and < 0.001, respectively). Overall, twenty-five comparisons for this variant (8652 obese patients and 10,075 non-obese controls) were recruited in this meta-analysis survey. A noteworthy association of UCP2 (rs659366) variant with obesity was identified among Asians and Africans but not Caucasians under allelic, dominant as well as heterozygote models. Nevertheless, this meta-analysis could not accomplish a noticeable association with overall subjects under different genetic models. This case-controlled study revealed a robust association for UCP2 (rs659366) variant with obesity susceptibility in Egyptian subjects; however, this meta-analysis survey failed to achieve an association for this variant with obesity in overall subjects except among Asians and Africans.

许多合格的文章研究了UCP2（rs659366）变异启动子区域的潜在影响以及肥胖症的易感性，结果令人怀疑。我们的团队设计了这种病例对照与荟萃分析调查相结合的方法，以说明这种变异对肥胖的贡献。该病例对照调查是根据110位肥胖的埃及患者和122位非肥胖对照制定的。利用PCR-RFLP技术扩增了基因组DNA，以确定UCP2（G-866A; rs659366）变异体。文献检索已完成，以调查该变异与肥胖的关系，该遗传来自各种遗传数据库。在本病例对照研究中，UCP2的分布（rs659366）在等位基因和显性模型下，变异体显​​示出与埃及受试者之间的肥胖显着相关（P值分别为0.0006和<0.001）。总体而言，该荟萃分析调查收集了该变异的25个比较（8652个肥胖患者和10,075个非肥胖对照）。在等位基因，显性和杂合子模型下，在亚洲人和非洲人中发现了UCP2（rs659366）变体与肥胖的显着关联，但在白种人中则没有。然而，这种荟萃分析无法与不同遗传模型下的总体受试者建立明显的关联。这项病例对照研究显示了与UCP2的强大关联（rs659366）埃及人易患肥胖症的变异体；然而，这项荟萃分析调查未能发现该变异体与肥胖症的整体相关性，亚洲人和非洲人除外。