Obesity is one of the main health concerns worldwide. Bariatric Surgery (BS) is the gold standard treatment for severe obesity. Nevertheless, unsatisfactory weight loss and complications can occur. The efficacy of BS is mainly defined on experiential bases; therefore, a more rational approach is required. The here reported activities aim to show the strength of experimental and computational biomechanics in evaluating stomach functionality depending on bariatric procedure. The experimental activities consisted in insufflation tests on samples of swine stomach to assess the pressure-volume behaviour both in pre- and post-surgical configurations. The investigation pertained to two main bariatric procedures: adjustable gastric banding (AGB) and laparoscopic sleeve gastrectomy (LSG). Subsequently, a computational model of the stomach was exploited to validate and to integrate results from experimental activities, as well as to broad the investigation to a wider scenario of surgical procedures and techniques. Furthermore, the computational approach allowed analysing stress and strain fields within stomach tissues because of food ingestion. Such fields elicit mechanical stimulation of gastric receptors, contributing to release satiety signals. Pressure-volume curves assessed stomach capacity and stiffness according to the surgical procedure. Both AGB and LSG proved to reduce stomach capacity and to increase stiffness, with markedly greater effect for LSG. At an internal pressure of 5 kPa, outcomes showed that in pre-surgical configuration the inflated volume was about 1000 mL, after AGB the inflated volume was slightly lower, while after LSG it fell significantly, reaching 100 mL. Computational modelling techniques showed the influence of bariatric intervention on mechanical stimulation of gastric receptors due to food ingestion. AGB markedly enhanced the mechanical stimulation within the fundus region, while LSG significantly reduced stress and strain intensities. Further computational investigations revealed the potentialities of hybrid endoscopic procedures to induce both reduction of stomach capacity and enhancement of gastric receptors mechanical stimulation. In conclusion, biomechanics proved to be useful for the investigation of BS effects. Future exploitations of the biomechanical methods may largely improve BS reliability, efficacy and penetration rate.

肥胖是全球主要的健康问题之一。减肥手术 (BS) 是治疗严重肥胖症的金标准。然而，可能会出现不理想的减肥效果和并发症。BS的功效主要是根据经验来定义的；因此，需要采取更合理的方法。此处报告的活动旨在显示实验和计算生物力学在根据减肥程序评估胃功能方面的优势。实验活动包括对猪胃样本进行充气测试，以评估手术前和手术后配置中的压力-体积行为。该调查涉及两个主要的减肥手术：可调节胃束带术 (AGB) 和腹腔镜袖状胃切除术 (LSG)。随后，利用胃的计算模型来验证和整合实验活动的结果，并将调查范围扩大到更广泛的外科手术和技术场景。此外，由于食物摄入，计算方法允许分析胃组织内的应力和应变场。这些场引起胃感受器的机械刺激，有助于释放饱腹感信号。压力-体积曲线根据外科手术评估胃容量和硬度。AGB 和 LSG 都被证明可以降低胃容量并增加硬度，对 LSG 的影响明显更大。在 5 kPa 的内部压力下，结果显示在术前配置中充气体积约为 1000 mL，AGB 后充气体积略低，而在 LSG 之后，它显着下降，达到 100 mL。计算建模技术显示了减肥干预对食物摄入引起的胃受体机械刺激的影响。AGB 显着增强了眼底区域内的机械刺激，而 LSG 显着降低了应力和应变强度。进一步的计算研究揭示了混合内窥镜手术诱导胃容量减少和胃受体机械刺激增强的潜力。总之，生物力学被证明可用于研究 BS 效应。生物力学方法的未来开发可能会在很大程度上提高 BS 的可靠性、有效性和普及率。计算建模技术显示了减肥干预对食物摄入引起的胃受体机械刺激的影响。AGB 显着增强了眼底区域内的机械刺激，而 LSG 显着降低了应力和应变强度。进一步的计算研究揭示了混合内窥镜手术诱导胃容量减少和胃受体机械刺激增强的潜力。总之，生物力学被证明可用于研究 BS 效应。生物力学方法的未来开发可能会在很大程度上提高 BS 的可靠性、有效性和普及率。计算建模技术显示了减肥干预对食物摄入引起的胃受体机械刺激的影响。AGB 显着增强了眼底区域内的机械刺激，而 LSG 显着降低了应力和应变强度。进一步的计算研究揭示了混合内窥镜手术诱导胃容量减少和胃受体机械刺激增强的潜力。总之，生物力学被证明可用于研究 BS 效应。生物力学方法的未来开发可能会在很大程度上提高 BS 的可靠性、有效性和普及率。而 LSG 显着降低了应力和应变强度。进一步的计算研究揭示了混合内窥镜手术诱导胃容量减少和胃受体机械刺激增强的潜力。总之，生物力学被证明可用于研究 BS 效应。生物力学方法的未来开发可能会在很大程度上提高 BS 的可靠性、有效性和普及率。而 LSG 显着降低了应力和应变强度。进一步的计算研究揭示了混合内窥镜手术诱导胃容量减少和胃受体机械刺激增强的潜力。总之，生物力学被证明可用于研究 BS 效应。生物力学方法的未来开发可能会在很大程度上提高 BS 的可靠性、有效性和普及率。