Radioactive iodine (RAI) therapy is an important treatment option for Graves’ disease (GD), the main side effect of RAI treatment is hypothyroidism, and the factors resulting in hypothyroidism are still controversial. The purpose of this retrospective study was to clarify the possible risk factors of early hypothyroidism after RAI therapy in Graves’ disease. We reviewed 312 GD patients treated with RAI between January 2017 to December 2018, collected the potential risk factors, and analyzed the relationship between these variables and early hypothyroidism. After 6 months’ follow-up, 218 (69.87%) patients were evaluated as early hypothyroid. Male gender, shorter duration of disease, smaller thyroid weight, lower 2-h radioactive iodine uptake (RAIU), 6-h RAIU, 24-h RAIU and 6/24-h uptake ratio, lower administered dosages were significantly associated with early hypothyroidism. Logistics regression analysis showed that male gender, smaller thyroid weight and lower 6-h RAIU were associated with early hypothyroidism. Multi-factors combined ROC curve analysis suggested that the predictive power of male gender, smaller thyroid weight and lower 6-h RAIU for early hypothyroidism was 0.711. Our results show that RAI is an effective therapy for GD and most of the cured patients became to hypothyroid within 6 months. Male gender, smaller thyroid weight and lower 6-h RAIU are the main risk factors for early hypothyroidism.

中文翻译：

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格雷夫斯病患者接受放射性碘治疗后早期甲状腺功能减退的预测因素。

放射性碘（RAI）治疗是治疗格雷夫斯病（GD）的重要选择，RAI治疗的主要副作用是甲状腺功能减退，导致甲状腺功能减退的因素仍存在争议。这项回顾性研究的目的是阐明Graves病中RAI治疗后早期甲状腺功能减退的可能危险因素。我们回顾了2017年1月至2018年12月间312例接受RAI治疗的GD患者，收集了潜在的危险因素，并分析了这些变量与早期甲状腺功能减退症之间的关系。经过6个月的随访，评估了218例（69.87％）患者为早期甲状腺功能减退。男性，疾病持续时间较短，甲状腺重量较小，2小时放射性碘摄取（RAIU）较低，6小时RAIU，24小时RAIU和6/24小时摄取率，较低的给药剂量与早期甲状腺功能减退显着相关。后勤回归分析显示，男性，甲状腺重量较小和6小时RAIU较低与早期甲状腺功能减退有关。多因素联合ROC曲线分析表明，男性，甲状腺较小的体重和较低的6-h RAIU对甲状腺功能减退症的预测能力为0.711。我们的结果表明，RAI是治疗GD的有效方法，大多数治愈的患者在6个月内转为甲状腺功能减退。男性，较小的甲状腺重量和较低的6小时RAIU是早期甲状腺功能减退的主要危险因素。多因素联合ROC曲线分析表明，男性，甲状腺较小的体重和较低的6-h RAIU对甲状腺功能减退症的预测能力为0.711。我们的结果表明，RAI是治疗GD的有效方法，大多数治愈的患者在6个月内变为甲状腺功能减退。男性，较小的甲状腺重量和较低的6小时RAIU是早期甲状腺功能减退的主要危险因素。多因素联合ROC曲线分析表明，男性，甲状腺较小的体重和较低的6-h RAIU对甲状腺功能减退症的预测能力为0.711。我们的结果表明，RAI是治疗GD的有效方法，大多数治愈的患者在6个月内转为甲状腺功能减退。男性，较小的甲状腺重量和较低的6小时RAIU是早期甲状腺功能减退的主要危险因素。