Purpose:

The purpose of this study was to assess visual function by visually evoked potentials in adults with orbital and other primary brain tumors affecting the optic pathway.

Methods:

In this retrospective case–control series, patients with orbital (intraconal and extraconal) or midline/chiasmatic tumors were included. Visually evoked potentials using pattern-reversal visually evoked potential and flash visually evoked potential stimuli were performed according to the international standards. Outcome measures were visually evoked potential parameters of amplitude (µV) and peak times (ms) measured both for the P100 component (pattern-reversal visually evoked potentials) and the N2P2 complex (flash visually evoked potential). Individual results were also compared with gender-based normative values.

Results:

A group of 21 adult patients (17 females) and age- and sex-matched controls were evaluated. Tumor location was intraconal (6 meningiomas, 3 hemangiomas, 1 glioma), extraconal (6 meningiomas), and midline (3 pituitary adenomas, 2 hypothalamic/chiasmatic low-grade gliomas). Abnormal fundus (76%), abnormal pupillary reflexes (71%), reduced visual acuity (62%), strabismus (48%), and proptosis (38%) were present. Visually evoked potential abnormalities were found in at least one eye of all cases. Affected eyes had significantly reduced amplitudes and prolonged peak times for pattern-reversal visually evoked potentials (p < .001) and significantly reduced amplitudes for flash visually evoked potential (p < .001). In unilateral orbital tumors, abnormally prolonged pattern-reversal visually evoked potential peak times were also detected in some contralateral eyes (n = 6/16).

Conclusion:

Visually evoked potential abnormalities were found in all adult patients with orbital and other intracranial primary tumors, even in eyes with normal exam and good visual acuity. Visually evoked potential can be used as a non-invasive ancillary test to characterize and monitor visual function in subjects with these neoplastic lesions.

中文翻译：

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通过视觉诱发电位评估患有眼眶和其他原发性颅内肿瘤的成人的视觉功能。

目的：

本研究的目的是通过视觉诱发电位评估成人眼眶和其他原发性脑肿瘤影响视神经通路的视觉功能。

方法：

在这个回顾性病例对照系列中，包括眼眶（圆锥内和圆锥外）或中线/交叉肿瘤的患者。根据国际标准进行使用模式反转视觉诱发电位和闪光视觉诱发电位刺激的视觉诱发电位。结果测量是针对 P100 分量（模式反转视觉诱发电位）和 N2P2 复合物（闪光视觉诱发电位）测量的幅度 (µV) 和峰值时间 (ms) 的视觉诱发电位参数。个人结果也与基于性别的规范值进行了比较。

结果：

评估了一组 21 名成年患者（17 名女性）和年龄和性别匹配的对照。肿瘤位于圆锥内（6 个脑膜瘤、3 个血管瘤、1 个神经胶质瘤）、圆锥外（6 个脑膜瘤）和中线（3 个垂体腺瘤、2 个下丘脑/交叉低级别神经胶质瘤）。存在眼底异常 (76%)、瞳孔反射异常 (71%)、视力下降 (62%)、斜视 (48%) 和眼球突出 (38%)。在所有病例中至少有一只眼睛发现了视觉诱发的潜在异常。受影响的眼睛显着降低了模式反转视觉诱发电位的振幅和延长的峰值时间 ( p  < .001)，并且显着降低了闪光视觉诱发电位的振幅 ( p < .001)。在单侧眼眶肿瘤中，在一些对侧眼中也检测到异常延长的模式反转视觉诱发电位峰值时间（n  = 6/16）。

结论：

在所有患有眼眶和其他颅内原发性肿瘤的成年患者中都发现了视觉诱发的潜在异常，即使在检查正常且视力良好的眼睛中也是如此。视觉诱发电位可用作非侵入性辅助测试，以表征和监测患有这些肿瘤性病变的受试者的视觉功能。