Using a statistical Z-score methodology, the yield data from 65 high-throughput acid screens and 45 base screens on synthetic intermediates were analyzed. The results show that salt screening outcomes are largely determined by the choice of counterions and solvents. We rank-ordered counterions, solvents, and counterion/solvent combinations and provided recommendations on how to carry out more productive high-throughput salt screening on synthetic intermediates.

中文翻译：

---

合成中间体的高通量盐筛选：溶剂，抗衡离子和抗衡离子溶解度的影响

使用统计的Z评分方法，分析了来自65个高通量酸筛和45个碱基筛的合成中间体的收率数据。结果表明，盐分筛选结果很大程度上取决于抗衡离子和溶剂的选择。我们对抗衡离子，溶剂和抗衡离子/溶剂的组合进行了排序，并就如何对合成中间体进行更具生产力的高通量盐筛选提供了建议。