Our idea is focused on the development of "monoclonal-type" plastic antibodies based on Molecularly Imprinted Polymers (MIPs) able to selectively bind a portion of the novel coronavirus SARS-CoV-2 spike protein to block its function and, thus, the infection process. Molecular Imprinting, indeed, represents a very promising and attractive technology for the synthesis of MIPs characterized by specific recognition abilities for a target molecule. Given these characteristics, MIPs can be considered tailor-made synthetic antibodies obtained by a templating process. In the present study, the developed imprinted polymeric nanoparticles were characterized in terms of particles size and distribution by Dynamic Light Scattering (DLS) and the imprinting effect and selectivity were investigated by performing binding experiments using the receptor-binding domain (RBD) of the novel coronavirus and the RBD of SARS-CoV spike protein, respectively. Finally, the hemocompatibility of the prepared MIP-based plastic antibodies was also evaluated.

中文翻译：

---

基于分子印迹聚合物的SARS-CoV-2的“单克隆型”塑料抗体

我们的想法集中在基于分子印迹聚合物（MIP）的“单克隆型”塑料抗体的开发上，该分子能够选择性结合部分新型冠状病毒SARS-CoV-2穗蛋白来阻断其功能，从而阻止感染处理。分子印迹确实代表了一种非常有前途且有吸引力的技术，用于合成以目标分子具有特定识别能力为特征的MIP。鉴于这些特性，可以将MIP视为通过模板过程获得的量身定制的合成抗体。在目前的研究中，利用动态光散射（DLS）对已开发的印迹聚合物纳米颗粒的粒径和分布进行了表征，并使用新型冠状病毒的受体结合域（RBD）和RBD的RBD进行了结合实验，研究了印迹效果和选择性。 SARS-CoV峰值蛋白分别。最后，还评估了所制备的基于MIP的塑料抗体的血液相容性。