Objective High frequency oscillations (HFOs) recorded by intracranial electrodes have generated excitement for their potential to help localize epileptic tissue for surgical resection. However, the number of HFOs per minute (i.e. the HFO “rate”) is not stable over the duration of intracranial recordings; for example, the rate of HFOs increases during periods of slow-wave sleep. Moreover, HFOs that are predictive of epileptic tissue may occur in oscillatory patterns due to phase coupling with lower frequencies. Therefore, we sought to further characterize between-seizure (i.e. “interictal”) HFO dynamics both within and outside the seizure onset zone (SOZ).

中文翻译：

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超越速率：高频振荡的时变动力学作为癫痫发作区的生物标志物

目的颅内电极记录的高频振荡 (HFO) 因其有助于定位癫痫组织以进行手术切除的潜力而令人兴奋。然而，在颅内记录期间，每分钟 HFO 的数量（即 HFO“速率”）并不稳定；例如，HFO 的比率在慢波睡眠期间会增加。此外，由于与较低频率的相位耦合，预测癫痫组织的 HFO 可能以振荡模式出现。因此，我们试图进一步描述癫痫发作区 (SOZ) 内外的癫痫发作间（即“发作间期”）HFO 动力学。