Neurons and immune cells have similar mechanisms for cell to cell communication. Exists active crosstalk between neurons and immune cells. Neurotransmitters can activate or inhibit immune cells, and cytokines modulate neuronal activity. The transcription factor Nur77 (NR4A1) is highly and transiently induced by several stimuli in neurons and T-lymphocytes, suggesting that Nur77 is involved in the coordination of the genetics response in both cell types. By analyzing publicly available databases, we found Nur77 target genes common to the nervous and immune systems. Functions as cell adhesion and anchoring appear as processes regulated by Nur77 in neurons and immune cells.

中文翻译：

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生物信息学方法揭示中枢神经和免疫系统共有的Nur77调控基因

神经元和免疫细胞具有相似的细胞间通讯机制。在神经元和免疫细胞之间存在活跃的串扰。神经递质可以激活或抑制免疫细胞，而细胞因子可以调节神经元的活动。转录因子Nur77（NR4A1）在神经元和T淋巴细胞中受到多种刺激而被高度短暂地诱导，这表明Nur77参与了两种细胞类型的遗传反应的协调。通过分析公共数据库，我们发现神经和免疫系统共有Nur77靶基因。Nur77在神经元和免疫细胞中调节细胞黏附和锚定功能。