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Visible Light-Driven Radical-Mediated C-C Bond Cleavage/Functionalization in Organic Synthesis.
Chemical Reviews ( IF 51.4 ) Pub Date : 2020-05-29 , DOI: 10.1021/acs.chemrev.0c00030 Xiao-Ye Yu 1 , Jia-Rong Chen 1 , Wen-Jing Xiao 1
Chemical Reviews ( IF 51.4 ) Pub Date : 2020-05-29 , DOI: 10.1021/acs.chemrev.0c00030 Xiao-Ye Yu 1 , Jia-Rong Chen 1 , Wen-Jing Xiao 1
Affiliation
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Thermal C–C bond cleavage reactions allow the construction of structurally diverse molecular skeletons via predictable and efficient bond reorganizations. Visible light photoredox-catalyzed radical-mediated C–C bond cleavage reactions have recently emerged as a powerful alternative method for overcoming the thermodynamic and kinetic barrier of C–C bond cleavage in diverse molecular scaffolds. In recent years, a plethora of elegant and useful reactions have been invented, and the products are sometimes otherwise inaccessible by classic thermal reactions. Considering the great influence and synthetic potential of these reactions, we provide a summary of the state of art visible light-driven radical-mediated C–C bond cleavage/functionalization strategies with a specific emphasis on the working models. We hoped that this review will be useful for medicinal and synthetic organic chemists and will inspire further reaction development in this interesting area.
中文翻译：
可见光驱动的自由基介导的CC键裂解/有机合成中的功能化。
C–C键热裂解反应可通过可预测和有效的键重组来构建结构多样的分子骨架。可见光光氧化还原催化的自由基介导的C–C键断裂反应已成为克服各种分子支架中C–C键断裂的热力学和动力学障碍的有效替代方法。近年来，已经发明了许多优雅而有用的反应，并且有时经典的热反应无法获得产品。考虑到这些反应的巨大影响和合成潜力，我们对可见光驱动的自由基介导的C–C键裂解/功能化策略进行了总结，特别强调了工作模型。
更新日期：2020-05-29
中文翻译：
可见光驱动的自由基介导的CC键裂解/有机合成中的功能化。
C–C键热裂解反应可通过可预测和有效的键重组来构建结构多样的分子骨架。可见光光氧化还原催化的自由基介导的C–C键断裂反应已成为克服各种分子支架中C–C键断裂的热力学和动力学障碍的有效替代方法。近年来，已经发明了许多优雅而有用的反应，并且有时经典的热反应无法获得产品。考虑到这些反应的巨大影响和合成潜力，我们对可见光驱动的自由基介导的C–C键裂解/功能化策略进行了总结，特别强调了工作模型。
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