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FATCAT 2.0: towards a better understanding of the structural diversity of proteins.
Nucleic Acids Research ( IF 16.6 ) Pub Date : 2020-05-29 , DOI: 10.1093/nar/gkaa443
Zhanwen Li 1 , Lukasz Jaroszewski 1 , Mallika Iyer 2 , Mayya Sedova 1 , Adam Godzik 1
Affiliation  

FATCAT 2.0 server (http://fatcat.godziklab.org/), provides access to a flexible protein structure alignment algorithm developed in our group. In such an alignment, rotations and translations between elements in the structure are allowed to minimize the overall root mean square deviation (RMSD) between the compared structures. This allows to effectively compare protein structures even if they underwent structural rearrangements in different functional forms, different crystallization conditions or as a result of mutations. The major update for the server introduces a new graphical interface, much faster database searches and several new options for visualization of the structural differences between proteins

中文翻译:

FATCAT 2.0:更好地理解蛋白质的结构多样性。

FATCAT 2.0服务器(http://fatcat.godziklab.org/)提供对我们小组中开发的灵活蛋白质结构比对算法的访问。在这样的对准中,允许结构中的元件之间的旋转和平移以最小化所比较的结构之间的整体均方根偏差(RMSD)。即使它们以不同的功能形式,不同的结晶条件或由于突变而经历了结构重排,这也可以有效地比较蛋白质结构。服务器的主要更新引入了新的图形界面,更快的数据库搜索以及用于可视化蛋白质之间结构差异的几个新选项
更新日期:2020-06-27
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