Retinoic Acid Is Elevated in the Mucosa of Patients With Active Ulcerative Colitis and Displays a Proinflammatory Role by Augmenting IL-17 and IFNγ Production.,Inflammatory Bowel Diseases

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Retinoic Acid Is Elevated in the Mucosa of Patients With Active Ulcerative Colitis and Displays a Proinflammatory Role by Augmenting IL-17 and IFNγ Production.
Inflammatory Bowel Diseases ( IF 4.5 ) Pub Date : 2020-05-29 , DOI: 10.1093/ibd/izaa121
Ritika Rampal ₁ , Nahidul Wari ₁ , Amit Kumar Singh ₁ , Ujjwalkumar Das ₂ , Sawan Bopanna ₁ , Vipin Gupta ₁ , Baibaswata Nayak ₁ , T Velapandian ₂ , Saurabh Kedia ₁ , Dhiraj Kumar ₃ , Amit Awasthi ₄ , Vineet Ahuja ₁

Affiliation

All-trans retinoic acid (RA) plays a crucial role in promoting Foxp3⁺ Treg generation while reciprocally inhibiting Th1/Th17 generation. Our previous research highlighted that in the face of inflammatory conditions, RA plays a contrary role where it aggravates intestinal inflammation by promoting interferon (IFN) γ and interleukin (IL)-17 differentiation in vitro.

中文翻译：

视黄酸在活动性溃疡性结肠炎患者的粘膜中升高，并通过增加 IL-17 和 IFNγ 的产生显示出促炎作用。

全反式视黄酸 (RA) 在促进 Foxp3 ⁺ Treg 生成同时相互抑制 Th1/Th17 生成方面起着至关重要的作用。我们之前的研究强调，在炎症条件下，RA 通过在体外促进干扰素 (IFN) γ 和白细胞介素 (IL)-17 分化而加重肠道炎症，从而起到相反的作用。

更新日期：2020-05-29

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