Reports of long-term oral anticoagulant (OAC) therapy for atrial fibrillation (AF) reveal highly variable, and generally suboptimal estimates of medication persistence. The objective of this review is to summarize current literature and highlight important methodological considerations for interpreting persistence research and designing studies of persistence on OAC treatment.

中文翻译：

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研究房颤中口服抗凝药物持久性的方法学考虑

长期口服抗凝剂（OAC）治疗房颤（AF）的报告显示，药物持久性存在很大差异，并且通常不是最佳估计。这篇综述的目的是总结当前的文献，并重点说明解释持久性研究和设计OAC治疗持久性研究的重要方法学方面的考虑。