The authors conducted this meta-analysis of randomized controlled trials (RCTs) to assess the effects of photobiomodulation therapy (PBMT) in the treatment of androgenic alopecia (AA). RCTs published in Pubmed, Web of Science, and Embase were systematically reviewed to identify the effects of PBMT in AA patients. The outcome measures included hair density and hair growth. Results were expressed as weighted mean difference (WMD) with 95% confidence interval (95%CI) and a risk ratio (RR) of 95%CI. A fixed-effects model or a randomized-effects model was performed according to the heterogeneity among the included studies. Nine RCTs met the inclusion criteria and were included in this meta-analysis. The mean change from baseline in hair density was 36.78 ± 23.84/cm2 in the PBMT group as compared with 8.88 ± 19.56/cm2 in the control group. Patients who received PBMT had a greater increase in hair density than those treated with a sham device (WMD = 18.56/cm2, 95%CI: 13.22, 23.89; P < 0.001). Moreover, PBMT was associated with a 42.43% increase in hair growth as compared with the sham device treatment (WMD = 42.43, 95%CI: 28.58, 56.28; P < 0.001). A greater rate of patients who were treated with PBMT achieved an improvement in hair regrowth than those with the sham device (RR = 1.32, 95%CI: 1.09, 1.58; P = 0.003). This study indicated that PBMT seemed to be a promising noninvasive treatment for patients with AA since it could improve hair density and stimulate hair growth. However, considering the potential limitations in this study, more large-scale RCTs are needed to verify our findings.The authors conducted this meta-analysis of randomized controlled trials (RCTs) to assess the effects of photobiomodulation therapy (PBMT) in the treatment of androgenic alopecia (AA). RCTs published in Pubmed, Web of Science, and Embase were systematically reviewed to identify the effects of PBMT in AA patients. The outcome measures included hair density and hair growth. Results were expressed as weighted mean difference (WMD) with 95% confidence interval (95%CI) and a risk ratio (RR) of 95%CI. A fixed-effects model or a randomized-effects model was performed according to the heterogeneity among the included studies. Nine RCTs met the inclusion criteria and were included in this meta-analysis. The mean change from baseline in hair density was 36.78 ± 23.84/cm2 in the PBMT group as compared with 8.88 ± 19.56/cm2 in the control group. Patients who received PBMT had a greater increase in hair density than those treated with a sham device (WMD = 18.56/cm2, 95%CI: 13.22, 23.89; P < 0.001). Moreover, PBMT was ...

中文翻译：

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光生物调节疗法对雄激素性脱发的影响：随机对照试验的荟萃分析

作者对随机对照试验 (RCT) 进行了这项荟萃分析，以评估光生物调节疗法 (PBMT) 在治疗雄激素性脱发 (AA) 中的效果。发表在 Pubmed、Web of Science 和 Embase 上的 RCT 被系统地审查，以确定 PBMT 对 AA 患者的影响。结果测量包括头发密度和头发生长。结果表示为具有 95% 置信区间 (95%CI) 和 95%CI 的风险比 (RR) 的加权平均差 (WMD)。根据纳入研究的异质性建立固定效应模型或随机效应模型。九项 RCT 符合纳入标准并被纳入本荟萃分析。PBMT 组头发密度自基线的平均变化为 36.78 ± 23.84/cm2，而对照组为 8.88 ± 19.56/cm2。接受 PBMT 的患者比接受假手术的患者的头发密度增加更多（WMD = 18.56/cm2，95%CI：13.22、23.89；P < 0.001）。此外，与假设备治疗相比，PBMT 与毛发生长增加 42.43% 相关（WMD = 42.43, 95% CI: 28.58, 56.28; P < 0.001）。与使用假手术装置的患者相比，接受 PBMT 治疗的患者毛发再生改善率更高（RR = 1.32，95%CI：1.09、1.58；P = 0.003）。这项研究表明，PBMT 似乎是 AA 患者的一种有前途的无创治疗方法，因为它可以改善头发密度并刺激头发生长。然而，考虑到本研究的潜在局限性，需要更大规模的 RCT 来验证我们的发现。作者对随机对照试验 (RCT) 进行了这项荟萃分析，以评估光生物调节疗法 (PBMT) 在治疗雄激素性脱发 (AA) 中的效果。发表在 Pubmed、Web of Science 和 Embase 上的 RCT 被系统地审查，以确定 PBMT 对 AA 患者的影响。结果测量包括头发密度和头发生长。结果表示为具有 95% 置信区间 (95%CI) 和 95%CI 的风险比 (RR) 的加权平均差 (WMD)。根据纳入研究的异质性建立固定效应模型或随机效应模型。九项 RCT 符合纳入标准并被纳入本荟萃分析。PBMT 组头发密度自基线的平均变化为 36.78 ± 23.84/cm2，而对照组为 8.88 ± 19.56/cm2。接受 PBMT 的患者比接受假手术的患者的头发密度增加更多（WMD = 18.56/cm2，95%CI：13.22、23.89；P < 0.001）。此外，PBMT 是...