Phallus luteus (Phallaceae), previously known as Dictyophora indusiata, is an edible and medicinal mushroom. As part of a continuing project to discover structurally and/or biologically novel natural products from wild mushrooms, we aimed to perform a chemical investigation of the methanol extract of P. luteus combined with a liquid chromatography–mass spectrometry-guided analysis coupled to an in-house UV spectral library. Two new sesquiterpenes, phallac acids A (1) and B (2), were isolated and determined. The chemical structure of the new natural products was unambiguously determined using a combination of 1D and 2D NMR and high-resolution electrospray ionization mass spectrometry data. To our knowledge, this is the first study to report linear sesquiterpene carboxylic acids from P. luteus. The new compounds were evaluated for α-glucosidase inhibitory activities where phallac acid B (2) showed α-glucosidase inhibitory potential (IC₅₀ value of 94.89 ± 5.57 μM) compared with the standard acarbose (IC₅₀ value of 26.23 ± 1.31 μM).

阴茎球菌（鬼笔科），以前称为竹荪，是可食用和药用蘑菇。作为从野生蘑菇中发现结构和/或生物学上新颖的天然产物的持续项目的一部分，我们旨在结合液相色谱-质谱联用和质谱联用对黄麻甲醇提取物进行化学研究。内部紫外光谱库。两种新的倍半萜烯，鬼臼酸A（1）和B（2），进行了隔离和确定。结合1D和2D NMR以及高分辨率电喷雾电离质谱数据，可以明确确定新天然产物的化学结构。据我们所知，这是第一个报道黄褐线虫中线性倍半萜烯羧酸的研究。与标准阿卡波糖（IC ₅₀值为26.23± 1.31μM ）相比，对新化合物的α-葡萄糖苷酶抑制活性进行了评估，其中鬼臼酸B（2）显示出α-葡萄糖苷酶抑制潜能（IC ₅₀值为94.89± 5.57μM ）。