Abstract

Carbonic anhydrase IX (CAIX) is a hypoxia-related protein considered as a predictor for oral squamous cell carcinoma (OSCC) biological behaviour. Nevertheless, this prognostic value is still yet to be validated. We aim to quantify prognostic significance of CAIX overexpression in OSCC by meta-analysis. We performed searches in MEDLINE, EMBASE, SCOPUS, WOS, WHO’S databases, CPCI, and OATD from inception to August 2019. Overall survival (OS), disease-free survival (DFS), locoregional control (LC), and disease-specific survival (DSS) were considered as outcomes of interest. Overall 18 studies were included. CAIX overexpression was associated with worse OS (hazard ratio [HR] = 1.45 95% confidence interval [CI] 1.17–1.80) and DFS (HR = 1.98 95% CI 1.18–3.32). To the contrary, it was neither associated with LC (HR = 1.01 95% CI 0.50–2.02) nor with DSS (HR = 1.35 95% CI 0.78–2.33). Heterogeneity was negligible in all analyses except for DSS. Small studies effect was not significant for OS and DFS. This study shows that immunohistochemical CAIX assessment is a useful OSCC prognostic biomarker.

摘要

碳酸酐酶IX（CAIX）是一种低氧相关蛋白，被认为是口腔鳞状细胞癌（OSCC）生物行为的预测因子。尽管如此，该预后价值仍有待验证。我们旨在通过荟萃分析量化CAIX在OSCC中过表达的预后意义。从开始到2019年8月，我们在MEDLINE，EMBASE，SCOPUS，WOS，WHO的数据库，CPCI和OATD中进行了搜索。总生存期（OS），无病生存期（DFS），局部区域控制（LC）和疾病特异性生存期（DSS）被视为感兴趣的结果。总共包括18个研究。CAIX过表达与OS恶化（危险比[HR] = 1.45 95％置信区间[CI] 1.17-1.80]和DFS（HR = 1.98 95％CI 1.18–3.32）相关。相反，它都不与LC相关（HR = 1.01 95％CI 0.50–2。02）或DSS（HR = 1.35 95％CI 0.78–2.33）。在所有分析中，除DSS外，异质性均可以忽略不计。小型研究对OS和DFS的影响不显着。这项研究表明，免疫组化CAIX评估是一种有用的OSCC预后生物标志物。