A series of 3-aryl indazoles and 1-methyl-3-aryl indazole derivatives are prepared with exceptional yields by coupling with several arylboronic acids and methylation by two dissimilar approaches. The as-prepared indazole derivatives (3a-3j) and their N-methyl derivatives (5a-5j) are evaluated for in vitro anticancer activity against two cancer cell lines, HCT-116 and MDA-MB-231. The results reveal that the indazole derivatives tested display mild to moderate anticancer activities against the cell lines tested.

中文翻译：

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Pd（PPh3）4催化合成吲唑衍生物作为有效的抗癌药物

通过与几种芳基硼酸偶合并通过两种不同的方法进行甲基化，可以以极高的收率制备一系列3-芳基吲唑和1-甲基-3-芳基吲唑衍生物。评价了所制备的吲唑衍生物（3a-3j）及其N-甲基衍生物（5a-5j）对两种癌细胞系HCT-116和MDA-MB-231的体外抗癌活性。结果表明，所测试的吲唑衍生物对所测试的细胞系显示出中等至中等的抗癌活性。