Osteoarthritis and inflammatory arthropathies are a cause of significant morbidity globally. New research elucidating the metabolic derangements associated with a variety of bone and joint disorders implicates various local and systemic metabolites, which further elucidate the underlying molecular mechanisms associated with these destructive disease processes. In osteoarthritis, atty acid metabolism has been implicated in disease development, both locally and systemically. Several series of rheumatoid arthritis patients have demonstrated overlapping trends related to histidine and glyceric acid, while other series showed similar results of increased cholesterol and glutamic acid. Studies comparing osteoarthritis and rheumatoid arthritis reported elevated gluconic acid and glycolytic- and tricarboxylic acid-related substrates in patients with osteoarthritis, while lysosphingolipids and cardiolipins were elevated only in patients with rheumatoid arthritis. Other bone and joint disorders, including osteonecrosis, intervertebral disc degeneration, and osteoporosis, also showed significant alterations in metabolic processes. The identification of the molecular mechanisms of osteoarthritis and inflammatory arthropathies via metabolomics-based workflows may allow for the development of new therapeutic targets to improve the quality of life in these patient populations.

中文翻译：

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变性骨骼和关节疾病特征的代谢组学分析。

骨关节炎和炎性关节病是全球范围内大量发病的原因。阐明与各种骨骼和关节疾病相关的代谢紊乱的新研究涉及各种局部和全身代谢产物，这进一步阐明了与这些破坏性疾病过程相关的潜在分子机制。在骨关节炎中，局部和全身都涉及酪氨酸代谢。类风湿性关节炎患者中有几个系列表现出与组氨酸和甘油酸相关的重叠趋势，而其他系列显示出胆固醇和谷氨酸升高的相似结果。比较骨关节炎和类风湿关节炎的研究报道，骨关节炎患者中葡萄糖酸，糖酵解和三羧酸相关底物升高，而糖脂和心磷脂仅在类风湿关节炎患者中升高。其他骨骼和关节疾病，包括骨坏死，椎间盘退变和骨质疏松症，也显示出代谢过程的显着改变。通过基于代谢组学的工作流程对骨关节炎和炎症性关节病的分子机制进行鉴定，可能有助于开发新的治疗靶标，以改善这些患者群体的生活质量。包括骨坏死，椎间盘退变和骨质疏松症，也显示出代谢过程的显着改变。通过基于代谢组学的工作流程对骨关节炎和炎症性关节病的分子机制进行鉴定，可能有助于开发新的治疗靶标，以改善这些患者群体的生活质量。包括骨坏死，椎间盘退变和骨质疏松症，也显示出代谢过程的显着改变。通过基于代谢组学的工作流程对骨关节炎和炎症性关节病的分子机制进行鉴定，可能有助于开发新的治疗靶标，以改善这些患者群体的生活质量。