Synthesis of Diketopiperazine Scaffolds with Tailored N‐ and α‐Chains by Selective Modification of Customizable Units,Advanced Synthesis & Catalysis

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Synthesis of Diketopiperazine Scaffolds with Tailored N‐ and α‐Chains by Selective Modification of Customizable Units
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2020-05-28 , DOI: 10.1002/adsc.202000470
Carlos J. Saavedra _{1,

2} , Fernando Cuevas _{1,

3} , Ivan Romero‐Estudillo ₃ , Alicia Boto ₁

Affiliation

The selective manipulation of Hyp customizable units in DKP substrates allows the generation of a rigid scaffold with four tailor‐made chains which are spatially‐orientated. The key step is a domino radical scission‐oxidation process which allows the generation of N‐substituted DKPs. The versatility of this methodology to produce scaffolds in high optical purity for material and drug discovery is described herein.

中文翻译：

通过定制化单元的选择性修饰合成具有定制N和α链的二酮哌嗪支架

在DKP基板中对Hyp可定制单元的选择性操作允许生成具有四个空间定向的量身定制链的刚性支架。关键步骤是多米诺骨牌断裂-氧化过程，该过程允许生成N取代的DKP。本文描述了这种方法的通用性，其以高光学纯度生产用于材料和药物发现的支架。

更新日期：2020-08-04

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