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A Facile Strategy to Fabricate Polysaccharide‐Based Magnetic Hydrogel Based on Enamine Bond†
Chinese Journal of Chemistry ( IF 5.5 ) Pub Date : 2020-05-29 , DOI: 10.1002/cjoc.201900523 Hongchen Liu 1, 2 , Jingru Yang 1 , Yunlei Yin 1 , Haisong Qi 2
Chinese Journal of Chemistry ( IF 5.5 ) Pub Date : 2020-05-29 , DOI: 10.1002/cjoc.201900523 Hongchen Liu 1, 2 , Jingru Yang 1 , Yunlei Yin 1 , Haisong Qi 2
Affiliation
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Magnetic hydrogels have found extensive applications in fields such as soft robotics, drug delivery and shape morphing. Here a facile method was fabricated to prepare polysaccharide‐based magnetic hydrogels. The chitosan‐Fe3O4 ferrofluid was obtained by dispersing carboxyl groups modified Fe3O4 nanoparticles uniformly in chitosan matrix. Subsequently, the magnetic polysaccharide hydrogel was obtained by simply mixing cellulose acetoacetate solution with chitosan‐Fe3O4 ferrofluid. The structures and properties of the magnetic hydrogel were analyzed using Fourier‐transform infrared spectroscopy, rheological recovery, responsiveness, and stability measurements. The results indicated that magnetic polysaccharide hydrogel showed pH responsiveness and excellent self‐healing properties, and the hydrogel manifested outstanding stability under physiological conditions (37 °C) for 72 h. In addition, the injectable polysaccharide‐based hydrogel exhibited sensitive magnetic responsive and shape‐shifting ability under an external magnetic field. Therefore, the strategy for the facile preparation of the magnetic polysaccharide‐based hydrogel in this work could provide a benign and versatile method for achieving self‐healing, responsive, injectable properties for the application in biomedical fields.
中文翻译：
一种基于烯胺键的基于多糖的磁性水凝胶制备策略
磁性水凝胶已在软机器人，药物输送和形状变形等领域中得到广泛应用。在这里，制造了一种简便的方法来制备基于多糖的磁性水凝胶。壳聚糖-Fe 3 O 4铁磁流体是通过将羧基改性的Fe 3 O 4纳米颗粒均匀分散在壳聚糖基质中而获得的。随后，只需将乙酰乙酸纤维素溶液与壳聚糖-Fe 3 O 4混合即可获得磁性多糖水凝胶。铁磁流体。使用傅里叶变换红外光谱，流变恢复，响应性和稳定性测量分析了磁性水凝胶的结构和性质。结果表明，磁性多糖水凝胶具有pH响应能力和优异的自愈特性，并且在生理条件下（37°C）72 h表现出出色的稳定性。此外，基于多糖的可注射水凝胶在外部磁场下表现出敏感的磁响应和形变能力。因此，在这项工作中轻松制备基于磁性多糖的水凝胶的策略可以为在生物医学领域中实现自愈，反应灵敏，可注射的特性提供良性且通用的方法。
更新日期：2020-05-29
中文翻译：
一种基于烯胺键的基于多糖的磁性水凝胶制备策略
磁性水凝胶已在软机器人，药物输送和形状变形等领域中得到广泛应用。在这里，制造了一种简便的方法来制备基于多糖的磁性水凝胶。壳聚糖-Fe 3 O 4铁磁流体是通过将羧基改性的Fe 3 O 4纳米颗粒均匀分散在壳聚糖基质中而获得的。随后，只需将乙酰乙酸纤维素溶液与壳聚糖-Fe 3 O 4混合即可获得磁性多糖水凝胶。铁磁流体。使用傅里叶变换红外光谱，流变恢复，响应性和稳定性测量分析了磁性水凝胶的结构和性质。结果表明，磁性多糖水凝胶具有pH响应能力和优异的自愈特性，并且在生理条件下（37°C）72 h表现出出色的稳定性。此外，基于多糖的可注射水凝胶在外部磁场下表现出敏感的磁响应和形变能力。因此，在这项工作中轻松制备基于磁性多糖的水凝胶的策略可以为在生物医学领域中实现自愈，反应灵敏，可注射的特性提供良性且通用的方法。
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