The wide spectrum of symptoms observed in coronavirus disease 2019 appears to defy explanation. Apart from geographic limitation to people with prior exposure to other coronaviruses and air pollutants, inflammatory comorbidities and older ages are also among the main factors of susceptibility to severe illness. The unusual epidemiological data pointed out in children and African territories have revealed new insights in host‐pathogen interplay with more focus on epigenetic regulation of cognitive compartments belonging to innate immunity. Should trained immunity be proven to be involved in timely immune responsiveness against severe acute respiratory syndrome coronavirus 2 and that adaptive memory could be detrimental, both treatment regimens and vaccine design will tremendously change accordingly with more focus on upper respiratory tissue innate immunity to subdue this threat underway.

中文翻译：

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在COVID-19中，受过训练的免疫力与适应性记忆的困惑问题。

在2019年的冠状病毒病中观察到的广泛症状似乎无视解释。除了地理上的限制，即事先接触过其他冠状病毒和空气污染物的人，炎症合并症和高龄人群也是易患严重疾病的主要因素。在儿童和非洲地区指出的不寻常的流行病学数据揭示了宿主与病原体相互作用的新见解，更多地关注属于先天免疫的认知区室的表观遗传调控。如果应证明训练有素的免疫力可及时针对严重的急性呼吸系统综合症冠状病毒2做出免疫反应，并且适应性记忆可能有害，