The glycoprotein stanniocalcin‐1 functions as a regulatory endocrine hormone that maintains the balance of calcium and phosphorus in bony fish and as a paracrine/autocrine factor involved in many physiological/pathological processes in humans, including carcinogenesis. In this review, we provide an overview of (a) the possible mechanisms through which STC1 affects the malignant properties of cancer, (b) transcriptional and post‐transcriptional regulation pathways of STC1 and (c) the potential clinical relevance of STC1 as a cancer biomarker and even a therapeutic target in the future. Exploring the role of STC1 in cancer development may provide a better understanding of the tumorigenesis process in humans and may facilitate finding an effective therapeutic method against cancer.

中文翻译：

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Stanniocalcin-1在癌症中的表达，功能及临床应用。

糖蛋白斯坦诺钙素-1充当调节性内分泌激素，可维持骨鱼中钙和磷的平衡，并作为涉及人类许多生理/病理过程（包括致癌作用）的旁分泌/自分泌因子。在这篇综述中，我们概述了（a）STC1影响癌症恶性特性的可能机制，（b）STC1的转录和转录后调控途径，以及（c）STC1作为癌症的潜在临床意义生物标志物，甚至是未来的治疗目标。探索STC1在癌症发展中的作用可以提供对人类肿瘤发生过程的更好理解，并可以促进寻找一种有效的抗癌治疗方法。