Pore-forming α subunits of the voltage- and Ca²⁺-activated K⁺ channel with large conductance (BKα) promote malignant phenotypes of breast tumour cells. Auxiliary subunits such as the leucine-rich repeat containing 26 (LRRC26) protein, also termed BKγ1, may be required to permit activation of BK currents at a depolarized resting membrane potential that frequently occur in non-excitable tumour cells.

中文翻译：

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在临床前模型中，BK 通道的亚基促进乳腺癌的发展并调节对内分泌治疗的反应

^{具有大电导（BKα）的电压和Ca 2+}激活的K ⁺通道的成孔α亚基促进乳腺肿瘤细胞的恶性表型。可能需要辅助亚基，例如富含亮氨酸的重复序列 26 (LRRC26) 蛋白，也称为 BKγ1，以允许在去极化的静息膜电位下激活 BK 电流，这种电位经常发生在不可兴奋的肿瘤细胞中。