Antiphospholipid syndrome is a organized autoimmune disease presented with vascular thrombosis and pregnancy morbidity. The Sapporo classification criteria of APS were revised in 2006 and are used as the main diagnosis guideline, which validity as standard measurements is still in debate. This study observe the clinical and laboratory indices of APS among Saudi patients. This is a retrospective study hospital-based population. The clinical and Laboratory manifestations of diagnosed APS patients from electronical medical records identifies by ICD-9 code 795.79 in the King Saud University Medical City, Riyadh, Saudi Arabia, between 1990 and 2012. We selected patients with ICD-9 code 795.79 as. Sapporo criteria applied to all patients, then divided into cases fulfilled criteria and cases failed the criteria. To notice the difference in clinical and laboratory indices and comorbidities between the two groups, the T-test was performed and Logistic regression for the fulfilled criteria and clinical indices of vascular thrombosis, DVT/PE, recurrent, and pregnancy morbidity. A total of 72 (90%) females and 8 (10%) males, with the female-to-male ratio 9:1. The mean (±SD) age at diagnosis was 28.1 (±8.7) years (range 11–63 years). There were 22 patients (27.5%) attained the revised criteria (APS confirmed) and no significant difference between the two groups was observed (p > 0.2). However, we found Sapporo confirmed APS cases had significantly higher percentage of serological manifestation presence than clinically diagnosed APS cases. Though there is no statistically significance, Sapporo confirmed APS cases had advanced odds of undergoing vascular thrombosis (OR = 1.61, 95%CI) and DVT/PE (OR = 1.53, 95%CI) and lesser odds of undergoing recurrent DVT/PE (OR = 0.67, 95%CI) and pregnancy morbidity (OR = 0.63, 95%CI) than the clinically diagnosed APS cases. Over 70% of the study population with diagnosed APS did not accomplish the revised Sapporo criteria due to negative laboratory manifestations, which reflects heterogeneous but not degreed disease severity profiles.

抗磷脂综合征是一种有组织的自身免疫性疾病，表现为血管血栓形成和妊娠合并症。APS的Sapporo分类标准于2006年进行了修订，并被用作主要的诊断指南，其作为标准测量的有效性仍在争论中。这项研究观察了沙特阿拉伯患者中APS的临床和实验室指标。这是一项基于医院的回顾性研究人群。从电子病历中诊断出的APS患者的临床和实验室表现由1990年至2012年间在沙特阿拉伯利雅得金沙特大学医学城的ICD-9代码795.79识别。我们选择了ICD-9代码795.79的患者。札幌标准适用于所有患者，然后分为符合条件的病例和不符合标准的病例。为了注意到两组之间在临床和实验室指标以及合并症方面的差异，进行了T检验，并通过Logistic回归分析了血管血栓形成，DVT / PE，复发和妊娠发病率的符合标准和临床指标。共有72位女性（占90％）和8位男性（占10％），男女之比为9：1。诊断时的平均年龄（±SD）为28.1（±8.7）岁（范围11-63岁）。有22例（27.5％）达到修订标准（已确认APS），两组之间未观察到显着差异（p> 0.2）。但是，我们发现札幌确诊的APS病例比临床诊断的APS病例具有更高的血清学表现百分比。尽管没有统计学意义，札幌确诊的APS病例发生血管血栓形成（OR = 1.61，95％CI）和DVT / PE（OR = 1.53，95％CI）的几率较高，复发DVT / PE（OR = 0.67，95％CI）的几率较低）和妊娠率（OR = 0.63，95％CI）高于临床诊断的APS病例。由于实验室表现阴性，超过70％的被诊断为APS的研究人群未达到修订的Sapporo标准，这反映出异质性但未确定病情严重程度。