The Multidomain Alzheimer Preventive Trial was designed to assess the effect of omega-3 supplementation and multidomain intervention on cognitive decline of subjects with subjective memory complaint. In terms of cognitive testing, no significant effect was found. In this paper, we evaluate the effect of the interventions on the brain morphological changes. Subjects with magnetic resonance imaging acquisitions at baseline and at 36 months were included (N = 376). Morphological changes were characterized by volume measurements and nonlinear deformation. The multidomain intervention was associated with a significant effect on the 3-year brain morphological changes in the deformation-based approach. Differences were mainly located in the left periventricular area next to the temporoparietal junction. These changes were associated with better cognitive performance and mood/behavior stabilization. No effect of the omega-3 supplementation was observed. This result suggests a possible effect on cognition, not yet observable after 3 years. We argue that neuroimaging could help define whether early intervention strategies are effective to delay cognitive decline and dementia.

中文翻译：

---

基于体素对 MAPT 队列中纵向大脑变化的治疗效果评估

多域阿尔茨海默病预防试验旨在评估补充 omega-3 和多域干预对主观记忆抱怨受试者认知能力下降的影响。在认知测试方面，未发现显着影响。在本文中，我们评估了干预对大脑形态变化的影响。包括在基线和 36 个月时进行磁共振成像采集的受试者（N = 376）。形态变化的特点是体积测量和非线性变形。在基于变形的方法中，多域干预与对 3 年大脑形态变化的显着影响有关。差异主要位于颞顶交界处旁边的左脑室周围区域。这些变化与更好的认知表现和情绪/行为稳定有关。没有观察到 omega-3 补充剂的影响。该结果表明可能对认知产生影响，但 3 年后尚无法观察到。我们认为，神经影像学可以帮助确定早期干预策略是否能有效延缓认知能力下降和痴呆症。