Pre-eclampsia is a significant risk factor for adverse outcomes for both the fetus and mother. Research has suggested that antiplatelet drugs, such as aspirin, could prevent pre-eclampsia, although meta-analyses have reported inconsistent outcomes. Therefore, we analyzed 12 such meta-analyses to provide a comprehensive overview of the effects of aspirin during pregnancy. Aspirin was associated with a significant reduction in pre-eclampsia, preterm labor, and intrauterine growth restriction (IUGR) if started at or before 16 weeks of gestational age. After 16 weeks, aspirin significantly reduced the incidence of preterm labor but did not influence IUGR. There was inconsistent evidence on the association between aspirin after 16 weeks of gestational age and pre-eclampsia, and on the association between aspirin and subgroups based on the time of pre-eclampsia onset (preterm versus term pre-eclampsia) and risk factors for pre-eclampsia (low versus high risk). Therefore, XXXXX.

先兆子痫是胎儿和母亲出现不良后果的重要危险因素。研究表明，抗血小板药物，如阿司匹林，可以预防先兆子痫，尽管荟萃分析报告了不一致的结果。因此，我们分析了 12 项此类荟萃分析，以全面概述阿司匹林在怀孕期间的作用。如果在孕 16 周或之前开始服用阿司匹林，可以显着减少先兆子痫、早产和宫内生长受限 (IUGR)。16 周后，阿司匹林显着降低了早产的发生率，但不影响 IUGR。关于孕 16 周后阿司匹林与先兆子痫之间关联的证据不一致，以及基于先兆子痫发作时间（早产与足月先兆子痫）和先兆子痫危险因素（低风险与高风险）的阿司匹林与亚组之间的关联。因此，XXXXX。