OBJECTIVES Establishing an overall survival prognosis for resected glioblastoma during routine postoperative management remains a challenge. The aim of our single-center study was to assess the usefulness of basing survival analyses on preradiotherapy MRI (PRMR) rather than on postoperative MRI (POMR). PATIENTS AND METHODS A retrospective review was undertaken of 75 patients with glioblastoma treated at our institute. We collected overall survival and MRI volumetric data. We analyzed two types of volumetric data: residual tumor volume and extent of resection. Overall survival rates were compared according to these two types of volumetric data, calculated on either POMR or PRMR and according to the presence or absence of residual enhancement. RESULTS Analysis of volumetric data revealed progression of some residual tumors between POMR and PRMR. Kaplan-Meier analysis of the correlations between extent of resection, residual tumor volume, and overall survival revealed significant differences between POMR and PRMR data. Both MRI scans indicated a difference between the complete resection subgroup and the incomplete resection subgroup, as median overall survival was longer in patients with complete resection. However, differences were significant for PRMR (25.3 vs. 15.5, p = 0.012), but not for POMR (21.3 vs. 15.8 months, p = 0.145). With a residual tumor volume cut-off value of 3 cm3, Kaplan-Meier survival analysis revealed non-significant differences on POMR (p = 0.323) compared with PRMR (p = 0.007). CONCLUSION Survival in patients with resected glioblastoma was more accurately predicted by volumetric data acquired with PRMR. Differences in predicted survival between the POMR and PRMR groups can be attributed to changes in tumor behavior before adjuvant therapy.

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与术后 MRI 残留体积相比，放疗前 MRI 更好地分析胶质母细胞瘤存活率：一项回顾性观察研究

目标 在常规术后管理期间确定切除的胶质母细胞瘤的总体生存预后仍然是一个挑战。我们的单中心研究的目的是评估基于放疗前 MRI (PRMR) 而不是术后 MRI (POMR) 的生存分析的有效性。患者和方法 我们对 75 名在我们研究所治疗​​的胶质母细胞瘤患者进行了回顾性研究。我们收集了总生存期和 MRI 体积数据。我们分析了两种类型的体积数据：残留肿瘤体积和切除范围。根据这两种类型的体积数据比较总生存率，根据 POMR 或 PRMR 以及根据残留增强的存在或不存在计算。结果 体积数据的分析揭示了 POMR 和 PRMR 之间一些残留肿瘤的进展。Kaplan-Meier 对切除范围、残留肿瘤体积和总生存期之间相关性的分析显示 POMR 和 PRMR 数据之间存在显着差异。两次 MRI 扫描都表明完全切除亚组和不完全切除亚组之间存在差异，因为完全切除患者的中位总生存期更长。然而，PRMR 的差异显着（25.3 对 15.5，p = 0.012），但对 POMR 不显着（21.3 对 15.8 个月，p = 0.145）。残留肿瘤体积截断值为 3 cm3，Kaplan-Meier 生存分析显示，与 PRMR (p = 0.007) 相比，POMR (p = 0.323) 无显着差异。结论 通过 PRMR 获得的体积数据可以更准确地预测切除的胶质母细胞瘤患者的存活率。